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Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Digestive diseases and sciences, 2015-11, Vol.60 (11), p.3318-3328

2015

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Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.415-423

2015

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Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1964-1970

2014

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Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

Toxicology and applied pharmacology, 2012-05, Vol.261 (1), p.1-9

2012

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Association of CYP2D6 and CYP2C19 metabolizer status with switching and discontinuing antidepressant drugs: an exploratory study

BMC psychiatry, 2024-05, Vol.24 (1), p.394-394, Article 394

2024

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Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites

Drug metabolism and disposition, 2013-06, Vol.41 (6), p.1179-1186

2013

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In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Clinical pharmacology and therapeutics, 2007-03, Vol.81 (3), p.406-413

2007

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Development of a Population Pharmacokinetic Model To Describe Azithromycin Whole-Blood and Plasma Concentrations over Time in Healthy Subjects

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3194-3201

2013

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Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1170-1178

2007

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Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis

British journal of clinical pharmacology, 2012-09, Vol.74 (3), p.445-455

2012

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Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation

The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.26-34

2010

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In Vivo Alterations in Drug Metabolism and Transport Pathways in Patients with Chronic Kidney Diseases

Pharmacotherapy, 2014-02, Vol.34 (2), p.114-122

2014

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Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes

The Journal of pharmacology and experimental therapeutics, 2006-09, Vol.318 (3), p.1068-1075

2006

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Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury

American journal of physiology: Gastrointestinal and liver physiology, 2018-05, Vol.314 (5), p.G597-G609

2018

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CT image biomarkers to improve patient-specific prediction of radiation-induced xerostomia and sticky saliva

Radiotherapy and oncology, 2017-02, Vol.122 (2), p.185-191

2017

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Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

The Journal of pharmacology and experimental therapeutics, 2020-05, Vol.373 (2), p.261-268

2020

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Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

Clinical pharmacology and therapeutics, 2015-04, Vol.97 (4), p.419-427

2015

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A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.6-17

2012

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Plasma Bile Acid Concentrations in Patients with Human Immunodeficiency Virus Infection Receiving Protease Inhibitor Therapy: Possible Implications for Hepatotoxicity

Pharmacotherapy, 2010-01, Vol.30 (1), p.17-24

2010

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Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential

European journal of gastroenterology & hepatology, 2014-10, Vol.26 (10), p.1073-1082

2014

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Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: Possible implications for radiotherapy treatment planning strategies

Radiotherapy and oncology, 2014-11, Vol.113 (2), p.198-203

2014

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Geometric Image Biomarker Changes of the Parotid Gland Are Associated With Late Xerostomia

International journal of radiation oncology, biology, physics, 2017-12, Vol.99 (5), p.1101-1110

2017

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Improving the prediction of overall survival for head and neck cancer patients using image biomarkers in combination with clinical parameters

Radiotherapy and oncology, 2017-08, Vol.124 (2), p.256-262

2017

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Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Pharmaceutical research, 2010-09, Vol.27 (9), p.1987

2010

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Selection of head and neck cancer patients for adaptive radiotherapy to decrease xerostomia

Radiotherapy and oncology, 2016-07, Vol.120 (1), p.36-40

2016

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Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

Novel mechanism of impaired function of organic anion-transporting polypeptide 1B3 in human hepatocytes: post-translational regulation of OATP1B3 by protein kinase C activation

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

Association of CYP2D6 and CYP2C19 metabolizer status with switching and discontinuing antidepressant drugs: an exploratory study

Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites

In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Development of a Population Pharmacokinetic Model To Describe Azithromycin Whole-Blood and Plasma Concentrations over Time in Healthy Subjects

Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity

Cyclophosphamide and 4‐hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis

Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation

In Vivo Alterations in Drug Metabolism and Transport Pathways in Patients with Chronic Kidney Diseases

Ritonavir, saquinavir, and efavirenz, but not nevirapine, inhibit bile acid transport in human and rat hepatocytes

Organic solute transporter OSTα/β is overexpressed in nonalcoholic steatohepatitis and modulated by drugs associated with liver injury

CT image biomarkers to improve patient-specific prediction of radiation-induced xerostomia and sticky saliva

Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk

Altered morphine glucuronide and bile acid disposition in patients with nonalcoholic steatohepatitis

A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair

Plasma Bile Acid Concentrations in Patients with Human Immunodeficiency Virus Infection Receiving Protease Inhibitor Therapy: Possible Implications for Hepatotoxicity

Medication use and medical comorbidity in patients with chronic hepatitis C from a US commercial claims database: high utilization of drugs with interaction potential

Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: Possible implications for radiotherapy treatment planning strategies

Geometric Image Biomarker Changes of the Parotid Gland Are Associated With Late Xerostomia

Improving the prediction of overall survival for head and neck cancer patients using image biomarkers in combination with clinical parameters

Evaluation of (99m)technetium-mebrofenin and (99m)technetium-sestamibi as specific probes for hepatic transport protein function in rat and human hepatocytes

Selection of head and neck cancer patients for adaptive radiotherapy to decrease xerostomia

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