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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

EMBO molecular medicine, 2017-09, Vol.9 (9), p.1183-1197

2017

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In vivo generated human CAR T cells eradicate tumor cells

Oncoimmunology, 2019-12, Vol.8 (12), p.e1671761-e1671761

2019

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In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

EMBO molecular medicine, 2018-11, Vol.10 (11), p.n/a

2018

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Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Molecular therapy. Methods & clinical development, 2019-03, Vol.12, p.19-31

2019

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Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

PLoS pathogens, 2016-06, Vol.12 (6), p.e1005641-e1005641

2016

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Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

EMBO molecular medicine, 2024-04, Vol.16 (4), p.784-804

2024

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Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Molecular therapy, 2013-01, Vol.21 (1), p.109-118

2013

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Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

Molecular therapy, 2022-07, Vol.30 (7), p.2401-2415

2022

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A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Frontiers in immunology, 2017-06, Vol.8, p.676-676

2017

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CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

Frontiers in immunology, 2023-08, Vol.14, p.1183698-1183698

2023

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DARPins: An Efficient Targeting Domain for Lentiviral Vectors

Molecular therapy, 2011-04, Vol.19 (4), p.686-693

2011

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Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

Frontiers in oncology, 2019-02, Vol.9, p.52-52

2019

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In vivo generation of CAR T cells in the presence of human myeloid cells

Molecular therapy. Methods & clinical development, 2022-09, Vol.26, p.144-156

2022

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APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Frontiers in cellular neuroscience, 2023-01, Vol.17, p.1106176-1106176

2023

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CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

PloS one, 2013-11, Vol.8 (11), p.e79047-e79047

2013

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Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

Molecular therapy. Methods & clinical development, 2023-03, Vol.28, p.90-98

2023

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Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.359-369

2021

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Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.334-347

2021

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Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo

PloS one, 2014-07, Vol.9 (7), p.e101644-e101644

2014

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Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.371-379

2019

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Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Trends in biotechnology (Regular ed.), 2015-12, Vol.33 (12), p.777-790

2015

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Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

iScience, 2021-03, Vol.24 (3), p.102170-102170, Article 102170

2021

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Virotherapy Research in Germany: From Engineering to Translation

Human gene therapy, 2017-10, Vol.28 (10), p.800

2017

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Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

PloS one, 2012-10, Vol.7 (10), p.e46667-e46667

2012

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CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Advanced science, 2023-12, Vol.10 (35), p.e2302992-n/a

2023

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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

In vivo generated human CAR T cells eradicate tumor cells

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

DARPins: An Efficient Targeting Domain for Lentiviral Vectors

Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

In vivo generation of CAR T cells in the presence of human myeloid cells

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

Virotherapy Research in Germany: From Engineering to Translation

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

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