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Prospects for Antibacterial Discovery and Development

Journal of the American Chemical Society, 2021-12, Vol.143 (50), p.21127-21142

2021

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Orally Absorbed Derivatives of the β‑Lactamase Inhibitor Avibactam. Design of Novel Prodrugs of Sulfate Containing Drugs

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10340-10344

2018

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In situ assembly of enzyme inhibitors using extended tethering

Nature biotechnology, 2003-03, Vol.21 (3), p.308-314

2003

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Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

Journal of medicinal chemistry, 1994-05, Vol.37 (10), p.1385-1401

1994

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Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

Journal of medicinal chemistry, 1994-04, Vol.37 (9), p.1233-1251

1994

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Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines

Journal of organic chemistry, 1996-02, Vol.61 (3), p.924-928

1996

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Exercise and rehabilitation of the cancer patient

Urologic oncology, 2008-03, Vol.26 (2), p.204-204

Gordon, Eric M., P.T

2008

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Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library

Journal of the American Chemical Society, 1995-07, Vol.117 (26), p.7029-7030

1995

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Combinatorial modification of natural products: Synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3409-3414

2003

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Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2

ACS medicinal chemistry letters, 2020-02, Vol.11 (2), p.162-165

2020

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Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.839-842

2006

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Selective Reduction of Peptide Isothiazolidin-3-ones

Organic letters, 2006-12, Vol.8 (25), p.5697-5699

2006

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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2906-2921

1995

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Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.5005-5022

2002

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Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams

Journal of the American Chemical Society, 1996-01, Vol.118 (1), p.253-254

1996

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Strategies for Combinatorial Organic Synthesis: Solution and Polymer-Supported Synthesis of 4-Thiazolidinones and 4-Metathiazanones Derived from Amino Acids

Journal of organic chemistry, 1995-11, Vol.60 (22), p.7328-7333

1995

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The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interaction

Journal of the American Chemical Society, 1991-10, Vol.113 (22), p.8522-8524

1991

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Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

Tetrahedron letters, 1996-07, Vol.37 (27), p.4643-4646

1996

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Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags

Journal of medicinal chemistry, 1996-04, Vol.39 (8), p.1601-1608

1996

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A general and efficient solid phase synthesis of quinazoline-2,4-diones

Tetrahedron letters, 1997-03, Vol.38 (10), p.1729-1732

1997

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Identification of potent and novel small-molecule inhibitors of caspase-3

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3651-3655

2003

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The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.707-712

1996

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Innovative approaches to novel antibacterial drug discovery

Current opinion in biotechnology, 1997-12, Vol.8 (6), p.757-762

1997

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Solid-Phase Synthesis of β-Sultams

Journal of organic chemistry, 1997-11, Vol.62 (23), p.8177-8181

1997

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Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2804-2815

1991

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1 – 25 von 1.319

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Prospects for Antibacterial Discovery and Development

Orally Absorbed Derivatives of the β‑Lactamase Inhibitor Avibactam. Design of Novel Prodrugs of Sulfate Containing Drugs

In situ assembly of enzyme inhibitors using extended tethering

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

Approaches to Combinatorial Synthesis of Heterocycles: A Solid-Phase Synthesis of 1,4-Dihydropyridines

Exercise and rehabilitation of the cancer patient

Combinatorial Organic Synthesis of Highly Functionalized Pyrrolidines: Identification of a Potent Angiotensin Converting Enzyme Inhibitor from a Mercaptoacyl Proline Library

Combinatorial modification of natural products: Synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2

Aminoethylenes: A Tetrahedral Intermediate Isostere Yielding Potent Inhibitors of the Aspartyl Protease BACE-1

Selective Reduction of Peptide Isothiazolidin-3-ones

Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Identification of Potent and Selective Small-Molecule Inhibitors of Caspase-3 through the Use of Extended Tethering and Structure-Based Drug Design

Solid-Supported Combinatorial Synthesis of Structurally Diverse β-Lactams

Strategies for Combinatorial Organic Synthesis: Solution and Polymer-Supported Synthesis of 4-Thiazolidinones and 4-Metathiazanones Derived from Amino Acids

The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interaction

Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines

Versatile Approach To Encoding Combinatorial Organic Syntheses Using Chemically Robust Secondary Amine Tags

A general and efficient solid phase synthesis of quinazoline-2,4-diones

Identification of potent and novel small-molecule inhibitors of caspase-3

The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries

Innovative approaches to novel antibacterial drug discovery

Solid-Phase Synthesis of β-Sultams

Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety

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