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PPARs: therapeutic targets for metabolic disease

Trends in pharmacological sciences (Regular ed.), 2005-05, Vol.26 (5), p.244-251

2005

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International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

Pharmacological reviews, 2006-12, Vol.58 (4), p.726-741

2006

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The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson’s disease

Scientific reports, 2021-04, Vol.11 (1), p.7934-13, Article 7934

2021

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Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21

PloS one, 2013-09, Vol.8 (9), p.e73011

2013

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Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12152-12162

2004

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Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells

Molecular & cellular proteomics, 2004-10, Vol.3 (10), p.960-969

2004

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Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo

Clinical cancer research, 2009-05, Vol.15 (10), p.3265-3276

2009

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Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs

Molecular pharmacology, 2011-12, Vol.80 (6), p.1156-1165

2011

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Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

Biochemical journal, 2009-03, Vol.418 (2), p.413-420

2009

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Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

Bioorganic & medicinal chemistry letters, 2009-07, Vol.19 (13), p.3398-3404

2009

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Retinaldehyde represses adipogenesis and diet-induced obesity

Nature medicine, 2007-06, Vol.13 (6), p.695-702

2007

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Inhibition of Cardiac Lipoprotein Utilization by Transgenic Overexpression of Angptl4 in the Heart

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (5), p.1767-1772

2005

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Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states

Molecular pharmacology, 2008-08, Vol.74 (2), p.403-412

2008

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A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis

PloS one, 2012-05, Vol.7 (5), p.e36384-e36384

2012

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Dual Roles for Lipolysis and Oxidation in Peroxisome Proliferation-Activator Receptor Responses to Electronegative Low Density Lipoprotein

The Journal of biological chemistry, 2003-10, Vol.278 (41), p.39874-39881

2003

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Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

European journal of pharmacology, 2013-09, Vol.715 (1-3), p.41-45

2013

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Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson’s disease

Neurogastroenterology and motility, 2020-03, Vol.32 (3), p.e13755-n/a

2020

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FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ

European journal of pharmacology, 2013-02, Vol.702 (1-3), p.302-308

2013

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Endothelial Cell-Targeted Deletion of PPAR γ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue

The Journal of pharmacology and experimental therapeutics, 2019-03, Vol.368 (3), p.514-523

2019

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2069-2073

2017

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Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8541-8554

2011

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Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue

The Journal of biological chemistry, 2001-11, Vol.276 (45), p.42077-42083

2001

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2063-2068

2017

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The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities

Molecular pharmacology, 2008-01, Vol.73 (1), p.62-74

2008

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Novel 2,3-Dihydrobenzofuran-2-carboxylic Acids: Highly Potent and Subtype-Selective PPARα Agonists with Potent Hypolipidemic Activity

Journal of medicinal chemistry, 2005-08, Vol.48 (17), p.5589-5599

2005

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PPARs: therapeutic targets for metabolic disease

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

The association of enteric neuropathy with gut phenotypes in acute and progressive models of Parkinson’s disease

Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21

Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity

Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells

Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo

Pharmacokinetic and pharmacodynamic properties of the glucokinase activator MK-0941 in rodent models of type 2 diabetes and healthy dogs

Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

Retinaldehyde represses adipogenesis and diet-induced obesity

Inhibition of Cardiac Lipoprotein Utilization by Transgenic Overexpression of Angptl4 in the Heart

Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states

A genome-wide siRNA screen to identify modulators of insulin sensitivity and gluconeogenesis

Dual Roles for Lipolysis and Oxidation in Peroxisome Proliferation-Activator Receptor Responses to Electronegative Low Density Lipoprotein

Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice

Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson’s disease

FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ

Endothelial Cell-Targeted Deletion of PPAR γ Blocks Rosiglitazone-Induced Plasma Volume Expansion and Vascular Remodeling in Adipose Tissue

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators

Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue

Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities

Novel 2,3-Dihydrobenzofuran-2-carboxylic Acids: Highly Potent and Subtype-Selective PPARα Agonists with Potent Hypolipidemic Activity

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