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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy

Trends in molecular medicine, 2020-09, Vol.26 (9), p.833-847

2020

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Regulation of protein tyrosine phosphatases by reversible oxidation

Journal of biochemistry (Tokyo), 2011-10, Vol.150 (4), p.345-356

2011

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The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

PloS one, 2020-12, Vol.15 (12), p.e0240498-e0240498

2020

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NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

Experimental hematology, 2016-12, Vol.44 (12), p.1113-1122

2016

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Transactivation joins multiple tracks to the ERK/MAPK cascade

Nature reviews. Molecular cell biology, 2003-08, Vol.4 (8), p.651-657

2003

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Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Journal of cellular and molecular medicine, 2020-04, Vol.24 (8), p.4668-4676

2020

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Protein-tyrosine phosphatases and cancer

Nature reviews. Cancer, 2006-04, Vol.6 (4), p.307-320

2006

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Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes

Circulation (New York, N.Y.), 2009-07, Vol.120 (2), p.150-159

2009

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Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

Scientific reports, 2018-10, Vol.8 (1), p.14684-13, Article 14684

2018

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SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells

Leukemia, 2020-05, Vol.34 (5), p.1444-1449

2020

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High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots

Molecular plant, 2015-08, Vol.8 (8), p.1253-1273

2015

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Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Molecular cell, 2009-10, Vol.36 (2), p.326-339

2009

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Activation mechanisms of STAT5 by oncogenic Flt3-ITD

Blood, 2007-07, Vol.110 (1), p.370-374

2007

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A phosphorylation-acetylation switch regulates STAT1 signaling

Genes & development, 2009-01, Vol.23 (2), p.223-235

2009

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Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation

Oncogene, 2019-06, Vol.38 (24), p.4773-4787

2019

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Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation

Redox biology, 2020-01, Vol.28, p.101325-101325, Article 101325

2020

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Protein tyrosine phosphatases: regulatory mechanisms

The FEBS journal, 2008-03, Vol.275 (5), p.831-847

2008

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Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay

PloS one, 2013-05, Vol.8 (5), p.e62871-e62871

2013

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The protein‐tyrosine phosphatase DEP‐1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase

Glia, 2017-02, Vol.65 (2), p.416-428

2017

Volltextzugriff (PDF)

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

Blood, 2009-04, Vol.113 (15), p.3568-3576

2009

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Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases

Molecular and Cellular Biology, 2005-05, Vol.25 (9), p.3690-3703

2005

Volltextzugriff (PDF)

In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1447, p.217

2016

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Blood, 2003-04, Vol.101 (8), p.3164-3173

2003

Volltextzugriff (PDF)

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Free radical biology & medicine, 2007-07, Vol.43 (1), p.100-110

2007

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Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2

BMC cancer, 2008-12, Vol.8 (1), p.380-380, Article 380

2008

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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy

Regulation of protein tyrosine phosphatases by reversible oxidation

The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

Transactivation joins multiple tracks to the ERK/MAPK cascade

Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Protein-tyrosine phosphatases and cancer

Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes

Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells

High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Activation mechanisms of STAT5 by oncogenic Flt3-ITD

A phosphorylation-acetylation switch regulates STAT1 signaling

Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation

Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation

Protein tyrosine phosphatases: regulatory mechanisms

Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay

The protein‐tyrosine phosphatase DEP‐1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases

In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2

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