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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy

Trends in molecular medicine, 2020-09, Vol.26 (9), p.833-847

2020

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NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

Experimental hematology, 2016-12, Vol.44 (12), p.1113-1122

2016

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Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Molecular cell, 2009-10, Vol.36 (2), p.326-339

2009

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Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Free radical biology & medicine, 2007-07, Vol.43 (1), p.100-110

2007

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Redox regulation of signal transduction in mammalian cells

Biochemical pharmacology, 2000, Vol.59 (1), p.35-41

2000

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Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[ b]furan-2-yl)methanones

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.2187-2197

2007

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A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

European journal of medicinal chemistry, 2020-05, Vol.193, p.112232, Article 112232

2020

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Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model

Vascular pharmacology, 2010-01, Vol.52 (1), p.55-62

2010

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Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole

European journal of medicinal chemistry, 2008-07, Vol.43 (7), p.1444-1453

2008

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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

Trends in Cell Biology, 2001-06, Vol.11 (6), p.258-266

2001

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Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Bioorganic & medicinal chemistry, 2003-05, Vol.11 (9), p.2007-2018

2003

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Monitoring phosphatase reactions of multiple phosphorylated substrates by reversed-phase HPLC

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-06, Vol.853 (1-2), p.204-213

2007

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Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells

Biochemical and biophysical research communications, 2009-10, Vol.388 (1), p.51-55

2009

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Selective protein kinase inhibitors block head-specific differentiation in hydra

Cellular signalling, 2000-10, Vol.12 (9), p.649-658

2000

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Investigation of protein-tyrosine phosphatases by in-gel assays

Methods (San Diego, Calif.), 2005, Vol.35 (1), p.22-27

2005

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Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells

European journal of cell biology, 2000-04, Vol.79 (4), p.261-271

2000

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Pyrrolo[3,4- c]-β-carboline-diones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

European journal of medicinal chemistry, 2000-04, Vol.35 (4), p.413-427

2000

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Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrr-olo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl) (4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

Bioorganic & medicinal chemistry, 2012, Vol.20 (1), p.125-136

2012

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The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet-derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein-tyrosine phosphatases

FEBS letters, 1993-10, Vol.331 (3), p.276-280

1993

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Inhibition of PDGFR tyrosine kinase activity by a series of novel N-3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl amides : A SAR study on the bioisosterism of pyrimidine and imidazole

European journal of medicinal chemistry, 2008, Vol.43 (7), p.1444-1453

2008

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Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1 H-imidazol-2-ylamino)phenyl)amides – A SAR study on the bioisosterism of pyrimidine and imidazole

European journal of medicinal chemistry, 2008, Vol.43 (7), p.1444-1453

2008

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Inhibition of FLT3 and PDGFR tyrosine kinase activity by his(benzo[b]furan-2-yl)methanones

Bioorganic & medicinal chemistry, 2007, Vol.15 (5), p.2187-2197

2007

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Hydrodynamic and circular dichroic analysis of mammary-derived growth inhibitor (MDGI)

Biochemical and biophysical research communications, 1989-05, Vol.161 (1), p.363-370

1989

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Antibodies against mammary derived growth inhibitor (MDGI) react with a fibroblast growth inhibitor and with heart fatty acid binding protein

Biochemical and biophysical research communications, 1987-11, Vol.148 (3), p.1425-1431

1987

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Specific neutralizing antiserum against a polypeptide growth inhibitor for mammary cells purified from bovine mammary gland

Biochimica et biophysica acta, 1985-07, Vol.846 (1), p.145-154

1985

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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy

NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Redox regulation of signal transduction in mammalian cells

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[ b]furan-2-yl)methanones

A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia

Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Monitoring phosphatase reactions of multiple phosphorylated substrates by reversed-phase HPLC

Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells

Selective protein kinase inhibitors block head-specific differentiation in hydra

Investigation of protein-tyrosine phosphatases by in-gel assays

Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells

Pyrrolo[3,4- c]-β-carboline-diones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrr-olo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl) (4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet-derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein-tyrosine phosphatases

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl amides : A SAR study on the bioisosterism of pyrimidine and imidazole

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1 H-imidazol-2-ylamino)phenyl)amides – A SAR study on the bioisosterism of pyrimidine and imidazole

Inhibition of FLT3 and PDGFR tyrosine kinase activity by his(benzo[b]furan-2-yl)methanones

Hydrodynamic and circular dichroic analysis of mammary-derived growth inhibitor (MDGI)

Antibodies against mammary derived growth inhibitor (MDGI) react with a fibroblast growth inhibitor and with heart fatty acid binding protein

Specific neutralizing antiserum against a polypeptide growth inhibitor for mammary cells purified from bovine mammary gland

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