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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy

Trends in molecular medicine, 2020-09, Vol.26 (9), p.833-847

2020

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The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

PloS one, 2020-12, Vol.15 (12), p.e0240498-e0240498

2020

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Transactivation joins multiple tracks to the ERK/MAPK cascade

Nature reviews. Molecular cell biology, 2003-08, Vol.4 (8), p.651-657

2003

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Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Journal of cellular and molecular medicine, 2020-04, Vol.24 (8), p.4668-4676

2020

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Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes

Circulation (New York, N.Y.), 2009-07, Vol.120 (2), p.150-159

2009

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Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

Scientific reports, 2018-10, Vol.8 (1), p.14684-13, Article 14684

2018

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SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells

Leukemia, 2020-05, Vol.34 (5), p.1444-1449

2020

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High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots

Molecular plant, 2015-08, Vol.8 (8), p.1253-1273

2015

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Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Molecular cell, 2009-10, Vol.36 (2), p.326-339

2009

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Activation mechanisms of STAT5 by oncogenic Flt3-ITD

Blood, 2007-07, Vol.110 (1), p.370-374

2007

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A phosphorylation-acetylation switch regulates STAT1 signaling

Genes & development, 2009-01, Vol.23 (2), p.223-235

2009

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Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation

Oncogene, 2019-06, Vol.38 (24), p.4773-4787

2019

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Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation

Redox biology, 2020-01, Vol.28, p.101325-101325, Article 101325

2020

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Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay

PloS one, 2013-05, Vol.8 (5), p.e62871-e62871

2013

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The protein‐tyrosine phosphatase DEP‐1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase

Glia, 2017-02, Vol.65 (2), p.416-428

2017

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Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

Blood, 2009-04, Vol.113 (15), p.3568-3576

2009

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Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases

Molecular and Cellular Biology, 2005-05, Vol.25 (9), p.3690-3703

2005

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PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells

Oncotarget, 2018-02, Vol.9 (10), p.9442-9455

2018

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Blood, 2003-04, Vol.101 (8), p.3164-3173

2003

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Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2

BMC cancer, 2008-12, Vol.8 (1), p.380-380, Article 380

2008

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Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells

Journal of cell science, 2013-10, Vol.126 (Pt 20), p.4746-4755

2013

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Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML

Oncotarget, 2017-12, Vol.8 (62), p.105440-105457

2017

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Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

Cell communication and signaling, 2012-07, Vol.10 (1), p.19-19, Article 19

2012

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Knockout of Density-Enhanced Phosphatase-1 Impairs Cerebrovascular Reserve Capacity in an Arteriogenesis Model in Mice

BioMed research international, 2013-01, Vol.2013, p.802149-9

2013

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GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage

Molecular nutrition & food research, 2009-10, Vol.53 (10), p.1245-1253

2009

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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy

The translation attenuating arginine-rich sequence in the extended signal peptide of the protein-tyrosine phosphatase PTPRJ/DEP1 is conserved in mammals

Transactivation joins multiple tracks to the ERK/MAPK cascade

Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Diabetes Mellitus Activates Signal Transduction Pathways Resulting in Vascular Endothelial Growth Factor Resistance of Human Monocytes

Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells

High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes

Activation mechanisms of STAT5 by oncogenic Flt3-ITD

A phosphorylation-acetylation switch regulates STAT1 signaling

Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation

Modulation of FLT3 signal transduction through cytoplasmic cysteine residues indicates the potential for redox regulation

Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay

The protein‐tyrosine phosphatase DEP‐1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases

PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

Role of cAMP in the promotion of colorectal cancer cell growth by prostaglandin E2

Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

Knockout of Density-Enhanced Phosphatase-1 Impairs Cerebrovascular Reserve Capacity in an Arteriogenesis Model in Mice

GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage

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