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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Nature (London), 2016-09, Vol.537 (7619), p.214-219

2016

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Late-stage oxidative C(sp3)–H methylation

Nature (London), 2020-04, Vol.580 (7805), p.621-627

2020

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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Angewandte Chemie International Edition, 2016-08, Vol.55 (33), p.9758-9762

International ed. in English, 2016

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Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.537-550

2023

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Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

Biotechnology journal, 2021-04, Vol.16 (4), p.e2000315-n/a

2021

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Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Organic process research & development, 2022-03, Vol.26 (3), p.616-623

2022

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Tetrahedron letters, 2013-12, Vol.54 (51), p.7065-7068

2013

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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-11, Vol.77 (22), p.10050-10057

2012

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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1948-1952

2011

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Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1051-1055

2013

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Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1046-1050

2013

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Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro

Chemical research in toxicology, 2011-02, Vol.24 (2), p.269-278

2011

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Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Angewandte Chemie, 2016-08, Vol.128 (33), p.9910-9914

2016

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The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Chemical biology & drug design, 2007-08, Vol.70 (2), p.100-112

2007

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Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5567-5572

2007

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

Organic process research & development, 2024-10, Vol.28 (10), p.3801-3807

2024

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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Organic process research & development, 2021-06, Vol.25 (6), p.1440-1453

2021

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Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

Chemical biology & drug design, 2007-06, Vol.69 (6), p.444-450

2007

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Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Journal of organic chemistry, 1998-07, Vol.63 (15), p.5088-5093

1998

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Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5410-5414

2013

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A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

Tetrahedron letters, 2006-10, Vol.47 (44), p.7677-7680

2006

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ChemInform Abstract: Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

ChemInform, 2016-11, Vol.47 (50), p.no-no

2016

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An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

Tetrahedron letters, 2000, Vol.41 (32), p.6041-6044

2000

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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Late-stage oxidative C(sp3)–H methylation

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

ChemInform Abstract: Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers

An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company

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