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Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

American journal of human genetics, 2013-08, Vol.93 (2), p.398-404

2013

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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Nature communications, 2019-08, Vol.10 (1), p.1-13, Article 3533

2019

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Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly

Journal of translational medicine, 2020-01, Vol.18 (1), p.27-27, Article 27

2020

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Regulation of Gene Expression by Cyclic GMP

Circulation research, 2003-11, Vol.93 (11), p.1034-1046

2003

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cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss

Journal of endocrinology, 2018-09, Vol.238 (3), p.203-219

2018

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An auto-inhibited state of protein kinase G and implications for selective activation

eLife, 2022-08, Vol.11

2022

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Letter by Casteel Regarding Article, “Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of the cGMP-Dependent Protein Kinase”

Circulation (New York, N.Y.), 2019-11, Vol.140 (22), p.e808-e809

Casteel, Darren E

2019

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Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding

PloS one, 2011-04, Vol.6 (4), p.e18413-e18413

2011

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Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes

Diabetes (New York, N.Y.), 2018-04, Vol.67 (4), p.607-623

2018

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A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice

Journal of bone and mineral research, 2017-01, Vol.32 (1), p.46-59

2017

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Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

The Journal of biological chemistry, 2018-07, Vol.293 (28), p.10985-10992

2018

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Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

Diabetes (New York, N.Y.), 2021-03, Vol.70 (3), p.665-679

2021

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Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice

Journal of bone and mineral research, 2023-01, Vol.38 (1), p.171-185

2023

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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B 12 analog

Nature communications, 2019-08, Vol.10 (1), p.3533

2019

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Constitutive protein kinase G activation exacerbates stress‐induced cardiomyopathy

British journal of pharmacology, 2022-06, Vol.179 (11), p.2413-2429

2022

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cGMP-dependent protein kinase Iβ regulates breast cancer cell migration and invasion via interaction with the actin/myosin-associated protein caldesmon

Journal of cell science, 2013-04, Vol.126 (Pt 7), p.1626-1636

2013

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Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

Scientific reports, 2020-11, Vol.10 (1), p.19907-19907, Article 19907

2020

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A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

The Journal of biological chemistry, 2009-02, Vol.284 (9), p.5807-5818

2009

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Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase

The American journal of pathology, 2017, Vol.187 (1), p.200-213

2017

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The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome

JACC. Basic to translational science, 2024-01, Vol.9 (1), p.46-62

2024

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Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

PNAS nexus, 2022-09, Vol.1 (4), p.pgac191-pgac191

2022

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cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity

Cellular signalling, 2008-07, Vol.20 (7), p.1392-1399

2008

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The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pockets

International journal of mass spectrometry, 2011-04, Vol.302 (1-3), p.44-52

2011

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Correction to: Crystal structure of PKG I[beta] holoenzyme reveals a trans-inhibiting dimer assembly

Journal of translational medicine, 2020-01, Vol.18 (1)

2020

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Structures of human PKG reveal cGMP-selectived activation mechanisms

BMC pharmacology & toxicology, 2013-08, Vol.14 (S1), p.O16-O16, Article O16

2013

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Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly

Regulation of Gene Expression by Cyclic GMP

cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss

An auto-inhibited state of protein kinase G and implications for selective activation

Letter by Casteel Regarding Article, “Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of the cGMP-Dependent Protein Kinase”

Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding

Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes

A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice

Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function

Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B 12 analog

Constitutive protein kinase G activation exacerbates stress‐induced cardiomyopathy

cGMP-dependent protein kinase Iβ regulates breast cancer cell migration and invasion via interaction with the actin/myosin-associated protein caldesmon

Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase

The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome

Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity

The amino terminus of cGMP-dependent protein kinase Iβ increases the dynamics of the protein's cGMP-binding pockets

Correction to: Crystal structure of PKG I[beta] holoenzyme reveals a trans-inhibiting dimer assembly

Structures of human PKG reveal cGMP-selectived activation mechanisms

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