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The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

Cell, 2018-09, Vol.174 (6), p.1347-1360

2018

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Cancer metabolism: fatty acid oxidation in the limelight

Nature reviews. Cancer, 2013-04, Vol.13 (4), p.227-232

2013

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Obesity and Cancer Mechanisms: Cancer Metabolism

Journal of clinical oncology, 2016-12, Vol.34 (35), p.4277-4283

2016

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AKT/PKB Signaling: Navigating Downstream

Cell, 2007-06, Vol.129 (7), p.1261-1274

2007

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Targeting the PI3K signaling pathway in cancer

Current opinion in genetics & development, 2010-02, Vol.20 (1), p.87-90

2010

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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Nature cell biology, 2016-05, Vol.18 (5), p.572-578

2016

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Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer

Metabolism in Cancer, 2016-01, Vol.207, p.39-72

2016

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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

The EMBO journal, 1997-07, Vol.16 (13), p.3877-3888

1997

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Acetate Fuels the Cancer Engine

Cell, 2014-12, Vol.159 (7), p.1492-1494

2014

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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

Molecular cell, 2011-12, Vol.44 (6), p.878-892

2011

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Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1778-1783

2016

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Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Breast cancer research : BCR, 2019-07, Vol.21 (1), p.78-78, Article 78

2019

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Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes

The EMBO journal, 1996-11, Vol.15 (21), p.5789-5795

1996

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What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

Cancer discovery, 2013-12, Vol.3 (12), p.1345-1354

2013

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Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Cell, 2018-11, Vol.175 (6), p.1546-1560.e17

2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Nature (London), 2009-12, Vol.462 (7274), p.739-744

2009

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Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer

Breast cancer research : BCR, 2020-11, Vol.22 (1), p.120-120, Article 120

2020

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

Nucleic acids research, 2003-07, Vol.31 (13), p.3635-3641

2003

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New Insights into Tumor Suppression: PTEN Suppresses Tumor Formation by Restraining the Phosphoinositide 3-kinase/AKT Pathway

Proceedings of the National Academy of Sciences - PNAS, 1999-04, Vol.96 (8), p.4240-4245

1999

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At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Nature reviews. Clinical oncology, 2022-07, Vol.19 (7), p.471-485

2022

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Current biology, 2022-02, Vol.32 (3), p.733-734

2022

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Current biology, 2003-08, Vol.13 (15), p.1259-1268

2003

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Tuberous Sclerosis Complex-1 and -2 Gene Products Function Together to Inhibit Mammalian Target of Rapamycin (mTOR)-Mediated Downstream Signaling

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (21), p.13571-13576

2002

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Large-Scale Characterization of HeLa Cell Nuclear Phosphoproteins

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.12130-12135

2004

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Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

Cancer cell, 2009-08, Vol.16 (2), p.115-125

2009

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The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

Cancer metabolism: fatty acid oxidation in the limelight

Obesity and Cancer Mechanisms: Cancer Metabolism

AKT/PKB Signaling: Navigating Downstream

Targeting the PI3K signaling pathway in cancer

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

Acetate Fuels the Cancer Engine

Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer

Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

New Insights into Tumor Suppression: PTEN Suppresses Tumor Formation by Restraining the Phosphoinositide 3-kinase/AKT Pathway

At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

Tuberous Sclerosis Complex-1 and -2 Gene Products Function Together to Inhibit Mammalian Target of Rapamycin (mTOR)-Mediated Downstream Signaling

Large-Scale Characterization of HeLa Cell Nuclear Phosphoproteins

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

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