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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

EMBO molecular medicine, 2017-09, Vol.9 (9), p.1183-1197

2017

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In vivo generated human CAR T cells eradicate tumor cells

Oncoimmunology, 2019-12, Vol.8 (12), p.e1671761-e1671761

2019

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Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Molecular therapy. Methods & clinical development, 2019-03, Vol.12, p.19-31

2019

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Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

EMBO molecular medicine, 2024-04, Vol.16 (4), p.784-804

2024

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A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Frontiers in immunology, 2017-06, Vol.8, p.676-676

2017

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Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

Frontiers in oncology, 2019-02, Vol.9, p.52-52

2019

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DARPins: An Efficient Targeting Domain for Lentiviral Vectors

Molecular therapy, 2011-04, Vol.19 (4), p.686-693

2011

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In vivo generation of CAR T cells in the presence of human myeloid cells

Molecular therapy. Methods & clinical development, 2022-09, Vol.26, p.144-156

2022

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Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.334-347

2021

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APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Frontiers in cellular neuroscience, 2023-01, Vol.17, p.1106176-1106176

2023

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Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

Molecular therapy. Methods & clinical development, 2023-03, Vol.28, p.90-98

2023

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CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

PloS one, 2013-11, Vol.8 (11), p.e79047-e79047

2013

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Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.371-379

2019

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Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.359-369

2021

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Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

iScience, 2021-03, Vol.24 (3), p.102170-102170, Article 102170

2021

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Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

PloS one, 2012-10, Vol.7 (10), p.e46667-e46667

2012

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CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Advanced science, 2023-12, Vol.10 (35), p.e2302992-n/a

2023

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Chimäre Antigenrezeptoren (CARs) in der Onkologie: eine Übersicht zu klinischer Anwendung und neuen Entwicklungen

Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2020, Vol.63 (11), p.1331-1340

2020

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Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory

Molecular therapy. Oncolytics, 2022-03, Vol.24, p.43-58

2022

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In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes

Molecular therapy, 2020-08, Vol.28 (8), p.1783-1794

2020

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Proceedings From the First International Workshop at Sidra Medicine: “Engineered Immune Cells in Cancer Immunotherapy (EICCI): From Discovery to Off-the-Shelf Development”, 15th–16th February 2019, Doha, Qatar

Frontiers in immunology, 2021-01, Vol.11, p.589381-589381

2021

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A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

Molecular therapy. Methods & clinical development, 2018-09, Vol.10, p.128-143

2018

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A new age of precision gene therapy

The Lancet (British edition), 2024-02, Vol.403 (10426), p.568-582

2024

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Enhancing the Oncolytic Activity of CD133-Targeted Measles Virus: Receptor Extension or Chimerism with Vesicular Stomatitis Virus Are Most Effective

Frontiers in oncology, 2017-06, Vol.7, p.127-127

2017

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CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes

Human gene therapy, 2020-06, Vol.31 (11-12), p.679-691

2020

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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

In vivo generated human CAR T cells eradicate tumor cells

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

DARPins: An Efficient Targeting Domain for Lentiviral Vectors

In vivo generation of CAR T cells in the presence of human myeloid cells

Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Monitoring CAR T cell generation with a CD8-targeted lentiviral vector by single-cell transcriptomics

Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Chimäre Antigenrezeptoren (CARs) in der Onkologie: eine Übersicht zu klinischer Anwendung und neuen Entwicklungen

Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory

In Vivo Generation of CAR T Cells Selectively in Human CD4+ Lymphocytes

Proceedings From the First International Workshop at Sidra Medicine: “Engineered Immune Cells in Cancer Immunotherapy (EICCI): From Discovery to Off-the-Shelf Development”, 15th–16th February 2019, Doha, Qatar

A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors

A new age of precision gene therapy

Enhancing the Oncolytic Activity of CD133-Targeted Measles Virus: Receptor Extension or Chimerism with Vesicular Stomatitis Virus Are Most Effective

CD8-Specific Designed Ankyrin Repeat Proteins Improve Selective Gene Delivery into Human and Primate T Lymphocytes

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