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Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2015-09, Vol.112 (39), p.E5381-E5390

2015

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Regulation of Protein Kinase Cβ I by Two Protein-Tyrosine Kinases, Btk and Syk

Proceedings of the National Academy of Sciences - PNAS, 2000-06, Vol.97 (13), p.7423-7428

2000

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The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (28)

2021

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Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (43), p.21539-21544

2019

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Structural basis for the recognition of the bacterial tyrosine kinase Wzc by its cognate tyrosine phosphatase Wzb

Proceedings of the National Academy of Sciences - PNAS, 2022-06, Vol.119 (26), p.e2201800119-e2201800119

2022

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Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (13), p.E2644-E2653

2017

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Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (52), p.20852-20857

2008

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Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation

Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (9), p.3524-3529

2019

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Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (31), p.E3177-E3186

2014

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MicroRNA Profiling Reveals Distinct Signatures in B Cell Chronic Lymphocytic Leukemias

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (32), p.11755-11760

2004

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Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13906-13911

2014

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Genetic modifiers of EGFR dependence in non-small cell lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18661-18666

2014

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Detection of a rare BCR–ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS)

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (40), p.16190-16195

2012

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Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk

Proceedings of the National Academy of Sciences - PNAS, 2017-11, Vol.114 (45), p.12027-12032

2017

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Cyclin-Dependent Kinase (CDK) Phosphorylation Destabilizes Somatic Wee1 via Multiple Pathways

Proceedings of the National Academy of Sciences - PNAS, 2005-08, Vol.102 (33), p.11663-11668

2005

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Activation of a Mitogen-Activated Protein Kinase Pathway is Involved in Disease Resistance in Tobacco

Proceedings of the National Academy of Sciences - PNAS, 2001-01, Vol.98 (2), p.741-746

2001

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Negative Regulation of Lck by Cbl Ubiquitin Ligase

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3794-3799

2002

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Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (49), p.20699-20704

2009

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Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state

Proceedings of the National Academy of Sciences - PNAS, 2023-02, Vol.120 (8), p.e2213090120-e2213090120

2023

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SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

Proceedings of the National Academy of Sciences - PNAS, 2023-11, Vol.120 (47), p.e2313137120-e2313137120

2023

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Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1

2021

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T-cell receptor complex is essential for Fas signal transduction

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (34), p.15105-15110

2010

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Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (40), p.20210-20217

2019

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My journey from tyrosine phosphorylation inhibitors to targeted immune therapy as strategies to combat cancer

Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (24), p.11579-11586

2019

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O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (10), p.e2107453119-e2107453119

2022

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Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors

Regulation of Protein Kinase Cβ I by Two Protein-Tyrosine Kinases, Btk and Syk

The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion

Lipid-targeting pleckstrin homology domain turns its autoinhibitory face toward the TEC kinases

Structural basis for the recognition of the bacterial tyrosine kinase Wzc by its cognate tyrosine phosphatase Wzb

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

MicroRNA Profiling Reveals Distinct Signatures in B Cell Chronic Lymphocytic Leukemias

Evolution of ibrutinib resistance in chronic lymphocytic leukemia (CLL)

Genetic modifiers of EGFR dependence in non-small cell lung cancer

Detection of a rare BCR–ABL tyrosine kinase fusion protein in H929 multiple myeloma cells using immunoprecipitation (IP)-tandem mass spectrometry (MS/MS)

Alk and Ltk ligands are essential for iridophore development in zebrafish mediated by the receptor tyrosine kinase Ltk

Cyclin-Dependent Kinase (CDK) Phosphorylation Destabilizes Somatic Wee1 via Multiple Pathways

Activation of a Mitogen-Activated Protein Kinase Pathway is Involved in Disease Resistance in Tobacco

Negative Regulation of Lck by Cbl Ubiquitin Ligase

Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

Gatekeeper mutations activate FGF receptor tyrosine kinases by destabilizing the autoinhibited state

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain

T-cell receptor complex is essential for Fas signal transduction

Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods

My journey from tyrosine phosphorylation inhibitors to targeted immune therapy as strategies to combat cancer

O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling

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