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Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry

Nature communications, 2022-11, Vol.13 (1), p.7246-14, Article 7246

2022

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For better drugs, diversify clinical trials

Science (American Association for the Advancement of Science), 2021-02, Vol.371 (6529), p.570-571

Bumpus, Namandjé N

2021

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Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

Biochemistry (Easton), 2016-11, Vol.55 (44), p.6087-6099

2016

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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Drug metabolism and disposition, 2019-10, Vol.47 (10), p.1122-1135

2019

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Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

AIDS research and human retroviruses, 2016-01, Vol.32 (1), p.32-43

2016

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Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain

PLoS genetics, 2023-01, Vol.19 (1), p.e1010558

2023

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Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice

Molecular pharmacology, 2014-01, Vol.85 (1), p.1-10

2014

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Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

Molecular pharmacology, 2021-12, Vol.100 (6), p.588-596

2021

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Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

Journal of medicinal chemistry, 2020-06, Vol.63 (12), p.6561-6574

2020

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Pharmacogenomics of Antiretroviral Drug Metabolism and Transport

Annual review of pharmacology and toxicology, 2021-01, Vol.61 (1), p.565-585

2021

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Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes

Toxicology and applied pharmacology, 2011-12, Vol.257 (2), p.227-234

Bumpus, Namandjé N.

2011

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A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1–Infected Adults on Antiretroviral Therapy

Clinical infectious diseases, 2014-03, Vol.58 (6), p.883-890

2014

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Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

Chemical research in toxicology, 2008-01, Vol.21 (1), p.189-205

2008

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MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema

The Journal of pharmacology and experimental therapeutics, 2018-10, Vol.367 (1), p.40-48

2018

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Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.803-814

2012

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Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc

Drug metabolism and disposition, 2012-12, Vol.40 (12), p.2221-2230

2012

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The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

Biochimica et biophysica acta. Gene regulatory mechanisms, 2023-06, Vol.1866 (2), p.194929-194929, Article 194929

2023

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Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1 α -XBP1

Molecular pharmacology, 2019-02, Vol.95 (2), p.183-195

2019

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Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.5067-5079

2013

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Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir

Pharmacogenomics, 2019-01, Vol.20 (2), p.105-111

2019

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Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study

PloS one, 2014-10, Vol.9 (10), p.e111507

2014

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Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

PloS one, 2018-04, Vol.13 (4), p.e0195764-e0195764

2018

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Tenofovir Activation Is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice

ACS pharmacology & translational science, 2024-01, Vol.7 (1), p.222-235

2024

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CYP3A5 genotype impacts maraviroc concentrations in healthy volunteers

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1796-1802

2014

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5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent

The Journal of pharmacology and experimental therapeutics, 2011-12, Vol.339 (3), p.886-895

2011

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Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry

For better drugs, diversify clinical trials

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities

Dose Frequency Ranging Pharmacokinetic Study of Tenofovir-Emtricitabine After Directly Observed Dosing in Healthy Volunteers to Establish Adherence Benchmarks (HPTN 066)

Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain

Valproic acid is a novel activator of AMP-activated protein kinase and decreases liver mass, hepatic fat accumulation, and serum glucose in obese mice

Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

Pharmacogenomics of Antiretroviral Drug Metabolism and Transport

Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1–Infected Adults on Antiretroviral Therapy

Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema

Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism

Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc

The SAGA HAT module is tethered by its SWIRM domain and modulates activity of the SAGA DUB module

Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1 α -XBP1

Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir

Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

Tenofovir Activation Is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice

CYP3A5 genotype impacts maraviroc concentrations in healthy volunteers

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent

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