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Structure and function of retroviral integrase

Nature reviews. Microbiology, 2022-01, Vol.20 (1), p.20-34

2022

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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (46), p.20057-20062

2010

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Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Nucleic acids research, 2014-04, Vol.42 (8), p.5164-5176

2014

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Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Science (American Association for the Advancement of Science), 2004-07, Vol.305 (5683), p.528-532

2004

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DNA binding specificities of Escherichia coli Cas1-Cas2 integrase drive its recruitment at the CRISPR locus

Nucleic acids research, 2017-03, Vol.45 (5), p.2714

2017

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Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572)

Molecular pharmacology, 2011-10, Vol.80 (4), p.565-572

2011

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Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

Antimicrobial Agents and Chemotherapy, 2011-10, Vol.55 (10), p.4552-4559

2011

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Structural basis for functional tetramerization of lentiviral integrase

PLoS pathogens, 2009-07, Vol.5 (7), p.e1000515-e1000515

2009

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Ubiquitination of non-lysine residues in the retroviral integrase

Biochemical and biophysical research communications, 2017-12, Vol.494 (1-2), p.57-62

2017

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Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

Antimicrobial agents and chemotherapy, 2014-06, Vol.58 (6), p.3233-3244

2014

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New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H

Antiviral research, 2016-10, Vol.134, p.236-243

2016

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Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (3), p.126784, Article 126784

2020

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Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors

Bioorganic chemistry, 2017-12, Vol.75, p.310-316

2017

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Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

Chembiochem : a European journal of chemical biology, 2015-11, Vol.16 (17), p.2507-2512

2015

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LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Retrovirology, 2013-05, Vol.10 (1), p.57-57, Article 57

2013

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Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes

PLoS pathogens, 2011-02, Vol.7 (2), p.e1001280

2011

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Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics

PloS one, 2013-10, Vol.8 (10), p.e77448

2013

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Synthesis and biological evaluation of bis-N 2 ,N 2 '-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides

Bioorganic & medicinal chemistry letters, 2020-03, Vol.30 (5), p.126911

2020

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Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus

Genesis (New York, N.Y. : 2000), 2004-10, Vol.40 (2), p.67-73

2004

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Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

Nature (London), 2019-07, Vol.571 (7764), p.219-225

2019

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C‑Terminal Domain of Integrase Binds between the Two Active Sites

Journal of chemical theory and computation, 2015-09, Vol.11 (9), p.4500-4511

Roberts, Victoria A

2015

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Targeting HIV-1 integrase with strand transfer inhibitors

Drug discovery today, 2015-04, Vol.20 (4), p.435-449

2015

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Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors

Viruses, 2020-08, Vol.12 (9), p.936

2020

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Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 Integrase

The Journal of biological chemistry, 2004-12, Vol.279 (53), p.55570-55577

2004

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The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

Retrovirology, 2014-11, Vol.11 (1), p.100, Article 100

2014

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Structure and function of retroviral integrase

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

DNA binding specificities of Escherichia coli Cas1-Cas2 integrase drive its recruitment at the CRISPR locus

Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572)

Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes

Structural basis for functional tetramerization of lentiviral integrase

Ubiquitination of non-lysine residues in the retroviral integrase

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors

Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors

Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes

Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics

Synthesis and biological evaluation of bis-N 2 ,N 2 '-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides

Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus

Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

C‑Terminal Domain of Integrase Binds between the Two Active Sites

Targeting HIV-1 integrase with strand transfer inhibitors

Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors

Lens Epithelium-derived Growth Factor/p75 Prevents Proteasomal Degradation of HIV-1 Integrase

The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase

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