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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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Critique of the two-fold measure of prediction success for ratios: application for the assessment of drug-drug interactions

Drug metabolism and disposition, 2011-02, Vol.39 (2), p.170-173

2011

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Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Pharmaceutical research, 2015-06, Vol.32 (6), p.1864-1883

2015

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Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

The AAPS journal, 2016-03, Vol.18 (2), p.321-332

2016

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Optimal Design of Pharmacokinetic Studies

Basic & clinical pharmacology & toxicology, 2010-03, Vol.106 (3), p.250-255

2010

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Investigation of simplified physiologically‐based pharmacokinetic models in rat and human

CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.333-345

2023

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A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.346-359

2023

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Mixed effects modeling of radiotherapy in combination with immune checkpoint blockade or inhibitors of the DNA damage response pathway

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1640-1652

2023

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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

European journal of pharmaceutical sciences, 2017-01, Vol.96, p.610-625

2017

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Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects

Pharmaceutical research, 2015-05, Vol.32 (5), p.1764-1778

2015

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Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

Journal of cerebral blood flow and metabolism, 2011-02, Vol.31 (2), p.439-447

2011

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Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat

Journal of pharmacy and pharmacology, 2012-03, Vol.64 (3), p.383-396

2012

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A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat

Pharmaceutical research, 2013-06, Vol.30 (6), p.1536-1552

2013

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Molecular Analysis of the Subgingival Microbiota in Health and Disease

Applied and Environmental Microbiology, 2007-01, Vol.73 (2), p.516-523

2007

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Phase I Trial of AEG35156 Administered as a 7-Day and 3-Day Continuous Intravenous Infusion in Patients With Advanced Refractory Cancer

Journal of clinical oncology, 2009-04, Vol.27 (10), p.1660-1666

2009

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Use of Nonlinear Mixed-Effects Analysis for Improved Precision of Early Pharmacodynamic Measures in Tuberculosis Treatment

Antimicrobial Agents and Chemotherapy, 2006-09, Vol.50 (9), p.3154-3156

2006

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Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

British journal of clinical pharmacology, 2015-01, Vol.79 (1), p.48-55

2015

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Physiologically based pharmacokinetic model for 6‐mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity

British journal of clinical pharmacology, 2015-07, Vol.80 (1), p.86-100

2015

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Sample Size/Power Calculations for Population Pharmacodynamic Experiments Involving Repeated-Count Measurements

Journal of biopharmaceutical statistics, 2010-09, Vol.20 (5), p.1026-1042

2010

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What do we mean by identifiability in mixed effects models?

Journal of pharmacokinetics and pharmacodynamics, 2016-02, Vol.43 (1), p.111-122

2016

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Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

Journal of pharmacokinetics and pharmacodynamics, 2010-02, Vol.37 (1), p.3-24

2010

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Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies

Antimicrobial Agents and Chemotherapy, 2011-06, Vol.55 (6), p.2775-2782

2011

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A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

Pharmaceutical research, 2015-01, Vol.32 (1), p.144-157

2015

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Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments

Journal of pharmacokinetics and pharmacodynamics, 2010-02, Vol.37 (1), p.67-83

2010

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Software for population pharmacokinetics and pharmacodynamics

Clinical pharmacokinetics, 1999-04, Vol.36 (4), p.255-264

AARONS, L

1999

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PBPK models for the prediction of in vivo performance of oral dosage forms

Critique of the two-fold measure of prediction success for ratios: application for the assessment of drug-drug interactions

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

Optimal Design of Pharmacokinetic Studies

Investigation of simplified physiologically‐based pharmacokinetic models in rat and human

A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

Mixed effects modeling of radiotherapy in combination with immune checkpoint blockade or inhibitors of the DNA damage response pathway

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects

Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study

Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat

Molecular Analysis of the Subgingival Microbiota in Health and Disease

Phase I Trial of AEG35156 Administered as a 7-Day and 3-Day Continuous Intravenous Infusion in Patients With Advanced Refractory Cancer

Use of Nonlinear Mixed-Effects Analysis for Improved Precision of Early Pharmacodynamic Measures in Tuberculosis Treatment

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Physiologically based pharmacokinetic model for 6‐mercpatopurine: exploring the role of genetic polymorphism in TPMT enzyme activity

Sample Size/Power Calculations for Population Pharmacodynamic Experiments Involving Repeated-Count Measurements

What do we mean by identifiability in mixed effects models?

Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin

Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies

A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments

Software for population pharmacokinetics and pharmacodynamics

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