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Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

Molecules (Basel, Switzerland), 2017-11, Vol.22 (12), p.2098

2017

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A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

Molecules (Basel, Switzerland), 2020-03, Vol.25 (5), p.1198

2020

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First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors

Chemical communications (Cambridge, England), 2014-02, Vol.50 (16), p.2043-2045

2014

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Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.498-505

2020

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Structure, activities and biomedical applications of human butyrylcholinesterase

Protein and peptide letters, 2009-10, Vol.16 (10), p.1215-1224

2009

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Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

European journal of medicinal chemistry, 2011-02, Vol.46 (2), p.811-818

2011

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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules (Basel, Switzerland), 2020-06, Vol.10 (6), p.858

2020

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Aging Pathways for Organophosphate-Inhibited Human Butyrylcholinesterase, Including Novel Pathways for Isomalathion, Resolved by Mass Spectrometry

Toxicological sciences, 2007-11, Vol.100 (1), p.136-145

2007

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Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Biochemical journal, 2013-08, Vol.453 (3), p.393-399

2013

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Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment

Molecules (Basel, Switzerland), 2010-12, Vol.15 (12), p.8804-8812

2010

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Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7683-7689

2016

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From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series

European journal of medicinal chemistry, 2022-04, Vol.234, p.114248-114248, Article 114248

2022

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N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.633-645

2017

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Purification of recombinant human butyrylcholinesterase on Hupresin

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018-12, Vol.1102-1103, p.109-115

2018

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Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation

European journal of medicinal chemistry, 2023-04, Vol.252, p.115301-115301, Article 115301

2023

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Pseudo-irreversible butyrylcholinesterase inhibitors: Structure–activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead

European journal of medicinal chemistry, 2023-02, Vol.247, p.115048, Article 115048

2023

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On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach

Chembiochem : a European journal of chemical biology, 2017-04, Vol.18 (7), p.666-675

2017

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Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.4002-4008

2010

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Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies

Bioorganic chemistry, 2023-05, Vol.134, p.106465-106465, Article 106465

2023

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Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

European journal of medicinal chemistry, 2023-03, Vol.249, p.115135, Article 115135

2023

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Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Chemical communications (Cambridge, England), 2014-04, Vol.50 (30), p.3947-3950

2014

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Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

European journal of medicinal chemistry, 2014-05, Vol.78, p.455-467

2014

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Grid‐Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions

Chembiochem : a European journal of chemical biology, 2022-12, Vol.23 (23), p.e202200456-n/a

2022

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A step toward the reactivation of aged cholinesterases – Crystal structure of ligands binding to aged human butyrylcholinesterase

Chemico-biological interactions, 2013-03, Vol.203 (1), p.19-23

2013

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Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides

First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes

Structure, activities and biomedical applications of human butyrylcholinesterase

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Aging Pathways for Organophosphate-Inhibited Human Butyrylcholinesterase, Including Novel Pathways for Isomalathion, Resolved by Mass Spectrometry

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment

Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Purification of recombinant human butyrylcholinesterase on Hupresin

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation

Pseudo-irreversible butyrylcholinesterase inhibitors: Structure–activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead

On the Influence of the Protonation States of Active Site Residues on AChE Reactivation: A QM/MM Approach

Structural Evidence That Human Acetylcholinesterase Inhibited by Tabun Ages through O-Dealkylation

Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies

Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase

Grid‐Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions

A step toward the reactivation of aged cholinesterases – Crystal structure of ligands binding to aged human butyrylcholinesterase

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