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First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors

Chemical communications (Cambridge, England), 2014-02, Vol.50 (16), p.2043-2045

2014

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Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

European journal of medicinal chemistry, 2011-02, Vol.46 (2), p.811-818

2011

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Aging Pathways for Organophosphate-Inhibited Human Butyrylcholinesterase, Including Novel Pathways for Isomalathion, Resolved by Mass Spectrometry

Toxicological sciences, 2007-11, Vol.100 (1), p.136-145

2007

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Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

Journal of medicinal chemistry, 2016-08, Vol.59 (16), p.7683-7689

2016

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From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series

European journal of medicinal chemistry, 2022-04, Vol.234, p.114248-114248, Article 114248

2022

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N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Bioorganic & medicinal chemistry, 2017-01, Vol.25 (2), p.633-645

2017

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Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation

European journal of medicinal chemistry, 2023-04, Vol.252, p.115301-115301, Article 115301

2023

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Pseudo-irreversible butyrylcholinesterase inhibitors: Structure–activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead

European journal of medicinal chemistry, 2023-02, Vol.247, p.115048, Article 115048

2023

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Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies

Bioorganic chemistry, 2023-05, Vol.134, p.106465-106465, Article 106465

2023

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Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

European journal of medicinal chemistry, 2023-03, Vol.249, p.115135, Article 115135

2023

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Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Chemical communications (Cambridge, England), 2014-04, Vol.50 (30), p.3947-3950

2014

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Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation

Journal of the American Chemical Society, 2008-11, Vol.130 (47), p.16011-16020

2008

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Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

Biochemical journal, 2009-07, Vol.421 (1), p.97-106

2009

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Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4523-4536

2009

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Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7593-7603

2009

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Energy Landscapes of Human Acetylcholinesterase and Its Huperzine A‑Inhibited Counterpart

The journal of physical chemistry. B, 2012-12, Vol.116 (51), p.14744-14753

2012

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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase

Analytical biochemistry, 2013-08, Vol.439 (2), p.132-141

2013

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Reaction site-driven regioselective synthesis of AChE inhibitors

Organic & biomolecular chemistry, 2014-01, Vol.12 (1), p.156-161

2014

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Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging

Biochemistry (Easton), 2005-02, Vol.44 (4), p.1154-1162

2005

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Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1763-1766

2010

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Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor

Journal of the American Chemical Society, 2006-04, Vol.128 (14), p.4526-4527

2006

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First enzymatic hydrolysis/thio-Michael addition cascade route to synthesis of AChE inhibitors

Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage – Implications for early Myasthenia gravis treatment

Aging Pathways for Organophosphate-Inhibited Human Butyrylcholinesterase, Including Novel Pathways for Isomalathion, Resolved by Mass Spectrometry

Discovery and Structure–Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening

From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer’s agents

Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

Pseudo-irreversible butyrylcholinesterase inhibitors: Structure–activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead

Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies

Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies

Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases

Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation

Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime

Energy Landscapes of Human Acetylcholinesterase and Its Huperzine A‑Inhibited Counterpart

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase

Reaction site-driven regioselective synthesis of AChE inhibitors

Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging

Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications

Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor

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