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3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction

Clinical pharmacology and therapeutics, 2023-06, Vol.113 (6), p.1284-1294

2023

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Drug metabolism and drug transport of the 100 most prescribed oral drugs

Basic & clinical pharmacology & toxicology, 2022-11, Vol.131 (5), p.311-324

2022

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Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children

Clinical pharmacology and therapeutics, 2018-07, Vol.104 (1), p.188-200

2018

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Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes

Placenta (Eastbourne), 2023-01, Vol.131, p.82-89

2023

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Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

PloS one, 2015-07, Vol.10 (7), p.e0132992

2015

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Interaction between Changan Granule and its main components in the plasma and CYP450 enzymes

Journal of ethnopharmacology, 2023-05, Vol.308, p.116303-116303, Article 116303

2023

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Computational simulations uncover enantioselective metabolism of chiral triazole fungicides by human CYP450 enzymes: A case study of tebuconazole

Ecotoxicology and environmental safety, 2024-10, Vol.284, p.116865, Article 116865

2024

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Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Clinical pharmacology and therapeutics, 2018-12, Vol.104 (6), p.1249-1259

2018

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Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

Drug metabolism and disposition, 2009-10, Vol.37 (10), p.2087-2094

2009

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CYP2C19 Plays a Major Role in the Hepatic N -Oxidation of Cotinine

Drug metabolism and disposition, 2023-01, Vol.51 (1), p.29-37

2023

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In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug–drug interactions

Pharmacological reports, 2020-06, Vol.72 (3), p.612-621

2020

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Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Basic & clinical pharmacology & toxicology, 2016-09, Vol.119 (3), p.284-290

2016

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Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

The Journal of biological chemistry, 2019-07, Vol.294 (28), p.10928-10941

2019

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Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Biochemistry (Easton), 2018-02, Vol.57 (5), p.817-826

2018

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Cytochrome b5 reductases: Redox regulators of cell homeostasis

The Journal of biological chemistry, 2022-12, Vol.298 (12), p.102654, Article 102654

2022

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Heterologous expression of high-activity cytochrome P450 in mammalian cells

Scientific reports, 2020-08, Vol.10 (1), p.14193, Article 14193

2020

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Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro

Drug metabolism and disposition, 2023-03, Vol.51 (3), p.293-305

2023

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Epsilonproteobacterial hydroxylamine oxidoreductase (εHao): characterization of a ‘missing link’ in the multihaem cytochrome c family

Molecular microbiology, 2017-07, Vol.105 (1), p.127-138

2017

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Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6

Xenobiotica, 2022-02, Vol.52 (2), p.199-208

2022

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Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities

Phytotherapy research, 2014-12, Vol.28 (12), p.1873-1878

2014

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Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently

Clinical pharmacokinetics, 2022-07, Vol.61 (7), p.1039-1055

2022

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Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1217-1228

2016

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Inhibition of human CYP1 enzymes by a classical inhibitor α‐naphthoflavone and a novel inhibitor N‐(3, 5‐dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study

Chemical biology & drug design, 2020-05, Vol.95 (5), p.520-533

2020

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Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

PloS one, 2014-04, Vol.9 (4), p.e93261-e93261

2014

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CYP450 Genotype/Phenotype Concordance in Mexican Amerindian Indigenous Populations-Where to from Here for Global Precision Medicine?

Omics (Larchmont, N.Y.), 2017-09, Vol.21 (9), p.509-519

2017

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3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction

Drug metabolism and drug transport of the 100 most prescribed oral drugs

Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children

Characterisation of cytochrome P450 isoenzyme activity in sheep liver and placental microsomes

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Interaction between Changan Granule and its main components in the plasma and CYP450 enzymes

Computational simulations uncover enantioselective metabolism of chiral triazole fungicides by human CYP450 enzymes: A case study of tebuconazole

Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P‐Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

CYP2C19 Plays a Major Role in the Hepatic N -Oxidation of Cotinine

In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug–drug interactions

Evaluation of Mutual Drug–Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method

Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

Use of Phenoxyaniline Analogues To Generate Biochemical Insights into the Interactio n of Polybrominated Diphenyl Ether with CYP2B Enzymes

Cytochrome b5 reductases: Redox regulators of cell homeostasis

Heterologous expression of high-activity cytochrome P450 in mammalian cells

Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro

Epsilonproteobacterial hydroxylamine oxidoreductase (εHao): characterization of a ‘missing link’ in the multihaem cytochrome c family

Spectroscopic observations of β-eudesmol binding to human cytochrome P450 isoforms 3A4 and 1A2, but not to isoforms 2C9, 2C19, and 2D6

Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities

Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently

Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes

Inhibition of human CYP1 enzymes by a classical inhibitor α‐naphthoflavone and a novel inhibitor N‐(3, 5‐dichlorophenyl)cyclopropanecarboxamide: An in vitro and in silico study

Differential expression of cytochrome P450 enzymes in normal and tumor tissues from childhood rhabdomyosarcoma

CYP450 Genotype/Phenotype Concordance in Mexican Amerindian Indigenous Populations-Where to from Here for Global Precision Medicine?

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