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Molecular mechanisms of retroviral integration site selection

Nucleic acids research, 2014-09, Vol.42 (16), p.10209

2014

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Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Science (American Association for the Advancement of Science), 2017-01, Vol.355 (6320), p.89-92

2017

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Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Science (American Association for the Advancement of Science), 2020-10, Vol.370 (6514), p.360-364

2020

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Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (8), p.2086-2091

2016

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Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (21), p.8690-8695

2013

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BET proteins promote efficient murine leukemia virus integration at transcription start sites

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.12036-12041

2013

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Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

The Journal of biological chemistry, 2012-05, Vol.287 (20), p.16801-16811

2012

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Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Nucleic acids research, 2013-04, Vol.41 (6), p.3924

2013

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Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

The Journal of biological chemistry, 2017-12, Vol.292 (48), p.19814-19825

2017

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Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

The Journal of biological chemistry, 2008-11, Vol.283 (46), p.31802-31812

2008

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Features of Double-stranded RNA-binding Domains of RNA Helicase A Are Necessary for Selective Recognition and Translation of Complex mRNAs

The Journal of biological chemistry, 2011-02, Vol.286 (7), p.5328-5337

2011

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A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

The Journal of biological chemistry, 2014-09, Vol.289 (38), p.26430-26440

2014

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FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

Nucleic acids research, 2011-11, Vol.39 (20), p.9009

2011

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Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Nucleic acids research, 2006-10, Vol.34 (18), p.5157

2006

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Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

The Journal of biological chemistry, 2009-09, Vol.284 (36), p.24213-24222

2009

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Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding

The Journal of biological chemistry, 2008-02, Vol.283 (9), p.5632-5641

2008

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Modulation of Replication Protein A Function by Its Hyperphosphorylation-induced Conformational Change Involving DNA Binding Domain B

The Journal of biological chemistry, 2005-09, Vol.280 (38), p.32775-32783

2005

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Pre-existing Distortions in Nucleic Acid Structure Aid Polypurine Tract Selection by HIV-1 Reverse Transcriptase

The Journal of biological chemistry, 2002-05, Vol.277 (19), p.16689-16696

2002

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High Resolution Footprinting of the Hepatitis C Virus Polymerase NS5B in Complex with RNA

The Journal of biological chemistry, 2007-06, Vol.282 (23), p.16907-16916

2007

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Structure of Hjc, A Holliday Junction Resolvase, from Sulfolobus solfataricus

Proceedings of the National Academy of Sciences - PNAS, 2001-05, Vol.98 (10), p.5509-5514

2001

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Identification of Specific HIV-1 Reverse Transcriptase Contacts to the Viral RNA:tRNA Complex by Mass Spectrometry and a Primary Amine Selective Reagent

Proceedings of the National Academy of Sciences - PNAS, 2002-12, Vol.99 (25), p.15988-15993

2002

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Identification of an Inhibitor-Binding Site to HIV-1 Integrase with Affinity Acetylation and Mass Spectrometry

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (18), p.6894-6899

2004

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Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

Nucleic acids research, 2016-06, Vol.44 (11), p.5344

2016

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LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Genes & development, 2015-11, Vol.29 (21), p.2287-2297

2015

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N 6 -Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

The Journal of biological chemistry, 2018-08, Vol.293 (34), p.12992

2018

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Molecular mechanisms of retroviral integration site selection

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Structure of the Brd4 ET domain bound to a C-terminal motif from γ-retroviral integrases reveals a conserved mechanism of interaction

Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation

BET proteins promote efficient murine leukemia virus integration at transcription start sites

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing

Dynamic Modulation of HIV-1 Integrase Structure and Function by Cellular Lens Epithelium-derived Growth Factor (LEDGF) Protein

Features of Double-stranded RNA-binding Domains of RNA Helicase A Are Necessary for Selective Recognition and Translation of Complex mRNAs

A Critical Role of the C-terminal Segment for Allosteric Inhibitor-induced Aberrant Multimerization of HIV-1 Integrase

FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75

Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites

Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

Subunit-specific Protein Footprinting Reveals Significant Structural Rearrangements and a Role for N-terminal Lys-14 of HIV-1 Integrase during Viral DNA Binding

Modulation of Replication Protein A Function by Its Hyperphosphorylation-induced Conformational Change Involving DNA Binding Domain B

Pre-existing Distortions in Nucleic Acid Structure Aid Polypurine Tract Selection by HIV-1 Reverse Transcriptase

High Resolution Footprinting of the Hepatitis C Virus Polymerase NS5B in Complex with RNA

Structure of Hjc, A Holliday Junction Resolvase, from Sulfolobus solfataricus

Identification of Specific HIV-1 Reverse Transcriptase Contacts to the Viral RNA:tRNA Complex by Mass Spectrometry and a Primary Amine Selective Reagent

Identification of an Inhibitor-Binding Site to HIV-1 Integrase with Affinity Acetylation and Mass Spectrometry

Use of chemical modification and mass spectrometry to identify substrate-contacting sites in proteinaceous RNase P, a tRNA processing enzyme

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

N 6 -Methyladenosine-binding proteins suppress HIV-1 infectivity and viral production

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