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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Nature communications, 2021-05, Vol.12 (1), p.2623-2623, Article 2623

2021

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Drug Intelligence Science (DIS®): Pioneering a high-resolution translational platform to enhance the probability of success for drug discovery and development

Drug discovery today, 2023-11, Vol.28 (11), p.103795-103795, Article 103795

Schweizer, Liang

2023

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Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Molecular cancer therapeutics, 2015-10, Vol.14 (10), p.2167-2174

2015

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Targeting epigenetic regulators for cancer therapy

Annals of the New York Academy of Sciences, 2014-02, Vol.1309 (1), p.30-36

2014

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Global or local: The future of biotech

Drug discovery today, 2023-05, Vol.28 (5), p.103528-103528, Article 103528

2023

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Safety, tolerability, pharmacokinetics, and immunogenicity of an anti-SARS-CoV-2 monoclonal antibody HFB30132A after single dose intravenous administration in healthy Chinese subjects: a phase 1, randomized, double-blind, placebo-controlled study

Frontiers in pharmacology, 2023-05, Vol.14, p.1117293-1117293

2023

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Guiding principles of value creation through collaborative innovation in pharmaceutical research

Drug discovery today, 2018-02, Vol.23 (2), p.213-218

2018

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A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

PloS one, 2016-06, Vol.11 (6), p.e0155909-e0155909

2016

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SDRS—an algorithm for analyzing large-scale dose–response data

Bioinformatics, 2011-10, Vol.27 (20), p.2921-2923

2011

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Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy

Cancer Growth and Metastasis, 2013-01, Vol.2013 (2013), p.53-59

2013

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Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds

Current chemical genomics and translational medicine, 2014-02, Vol.8 (1), p.16-26

2014

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Requirement for Pangolin/dTCF in Drosophila Wingless Signaling

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.5846-5851

2003

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Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells

Molecular biology of the cell, 1998-12, Vol.9 (12), p.3505-3519

1998

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Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Development (Cambridge), 2004-10, Vol.131 (20), p.5103-5115

2004

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Abstract 6532: HFB9-2: A novel Gal-9 neutralizing antibody to reverse immune suppression in the tumor microenvironment

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6532-6532

2020

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High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics

Science advances, 2021-06, Vol.7 (24)

2021

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Abstract PO-048: Combined single-T cell clonotyping and phenotyping defines a predictive response signature that identifies patients more likely to respond to therapy

Cancer research (Chicago, Ill.), 2020-11, Vol.80 (21_Supplement), p.PO-048-PO-048

2020

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Abstract 7176: Optimization of T cell co-stimulatory agonists: A semi-mechanistic PKPD model integrating drug properties and tumor-immune interactions

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.7176-7176

2024

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Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Bioorganic & medicinal chemistry letters, 2024-01, Vol.98, p.129589-129589, Article 129589

2024

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Abstract 1843: Dicovery and characterization of a novel anti-human CXCR5 antibody for the treatment of B cell lymphomas

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1843-1843

2021

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Abstract 2282: Discovery and characterization of novel TNFR2 antibodies to modulate T cell activities in immunosuppressive environment

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2282-2282

2020

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Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1883-1883

2021

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Abstract 1882: Clinical approach and biomarker strategy for HFB301001, a novel OX40 agonistic antibody

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1882-1882

2021

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Abstract 1884: HFB9-2, a novel Galectin 9 neutralizing antibody for the treatment of AML and other cancers

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1884-1884

2021

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Abstract 6202: Integrating public single-cell transcriptomics and patient profiles to guide clinical development

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.6202-6202

2024

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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Drug Intelligence Science (DIS®): Pioneering a high-resolution translational platform to enhance the probability of success for drug discovery and development

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Targeting epigenetic regulators for cancer therapy

Global or local: The future of biotech

Safety, tolerability, pharmacokinetics, and immunogenicity of an anti-SARS-CoV-2 monoclonal antibody HFB30132A after single dose intravenous administration in healthy Chinese subjects: a phase 1, randomized, double-blind, placebo-controlled study

Guiding principles of value creation through collaborative innovation in pharmaceutical research

A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

SDRS—an algorithm for analyzing large-scale dose–response data

Enhancing Cancer Drug Discovery through Novel Cell Signaling Pathway Panel Strategy

Establishing a High-content Analysis Method for Tubulin Polymerization to Evaluate Both the Stabilizing and Destabilizing Activities of Compounds

Requirement for Pangolin/dTCF in Drosophila Wingless Signaling

Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Abstract 6532: HFB9-2: A novel Gal-9 neutralizing antibody to reverse immune suppression in the tumor microenvironment

High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics

Abstract PO-048: Combined single-T cell clonotyping and phenotyping defines a predictive response signature that identifies patients more likely to respond to therapy

Abstract 7176: Optimization of T cell co-stimulatory agonists: A semi-mechanistic PKPD model integrating drug properties and tumor-immune interactions

Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Abstract 1843: Dicovery and characterization of a novel anti-human CXCR5 antibody for the treatment of B cell lymphomas

Abstract 2282: Discovery and characterization of novel TNFR2 antibodies to modulate T cell activities in immunosuppressive environment

Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer

Abstract 1882: Clinical approach and biomarker strategy for HFB301001, a novel OX40 agonistic antibody

Abstract 1884: HFB9-2, a novel Galectin 9 neutralizing antibody for the treatment of AML and other cancers

Abstract 6202: Integrating public single-cell transcriptomics and patient profiles to guide clinical development

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