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N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

MedChemComm, 2018, Vol.9 (6), p.963-968

2018

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Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators

Bioorganic & medicinal chemistry, 2023-05, Vol.87, p.117303-117303, Article 117303

2023

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Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8515-8537

2017

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Chryso-lactams:Gold(I) derivatives of ampicillin with specific activity against Gram-positive pathogens

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (9), p.127098-127098, Article 127098

2020

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1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

Bioorganic & medicinal chemistry letters, 2021-05, Vol.40, p.127879-127879, Article 127879

2021

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Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Antiviral research, 2017-08, Vol.144, p.330-339

2017

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Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

Antiviral research, 2019-03, Vol.163, p.59-69

2019

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Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs

ACS medicinal chemistry letters, 2019-05, Vol.10 (5), p.754-760

2019

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Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF-[kappa]B and Its Ligand

ChemMedChem, 2017-10, Vol.12 (20), p.1697

2017

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4-Hydroxy- N -[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade

MedChemComm, 2017-09, Vol.8 (9), p.1850-1855

2017

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Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF‐κB and Its Ligand

ChemMedChem, 2017-10, Vol.12 (20), p.1697-1702

2017

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N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIKElectronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, and biochemical protocols. See DOI: 10.1039/c8md00068a

2018-06

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N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK† †Electronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, and biochemical protocols. See DOI: 10.1039/c8md00068a

MedChemComm, 2018-04, Vol.9 (6), p.963-968

2018

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Fragment pharmacophore-based in silico screening: a powerful approach for efficient lead discoveryThe authors declare no competing interests

2016-03

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Fragment pharmacophore-based in silicoscreening: a powerful approach for efficient lead discovery

MedChemComm, 2016-03, Vol.7 (3), p.506-511

2016

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Fragment pharmacophore-based in silico screening: a powerful approach for efficient lead discovery

MedChemComm, 2016-03, Vol.7 (3), p.506-511

2016

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4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascadeElectronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, biochemical protocols. See DOI: 10.1039/c7md00278e

2017-09

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4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade† †Electronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, biochemical protocols. See DOI: 10.1039/c7md00278e

MedChemComm, 2017-08, Vol.8 (9), p.1850-1855

2017

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Structural, Magnetic, and Dynamic Characterization of the (d xz ,d y z )4(d x y )1 Ground-State Low-Spin Iron(III) Tetraphenylporphyrinate Complex [(p-TTP)Fe(2,6-XylylNC)2]CF3SO3

Journal of the American Chemical Society, 2000-05, Vol.122 (18), p.4366-4377

2000

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Palladium Assisted Substitution of 3-Benzo[b]furan Triflates

Synlett, 2002, Vol.2002 (3), p.501-503

2002

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Synthesis of constrained arylpiperidines using intramolecular Heck or radical reactions

Tetrahedron letters, 2001-09, Vol.42 (37), p.6499-6502

2001

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Synthesis and Characterization of Low-Spin Bis(amino ester) Iron(III) Porphyrin Complexes

Inorganic chemistry, 1998-11, Vol.37 (23), p.6100-6103

1998

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Oxidation of amino esters to imine complexes with chiral high-valent oxoruthenium porphyrins

Inorganica Chimica Acta, 1998-05, Vol.273 (1), p.142-150

1998

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Oxidation and chiral recognition of amino esters by dioxoruthenium(VI) porphyrins: Synthesis of new imino ester Ru (II) complexes

Tetrahedron letters, 1996-09, Vol.37 (37), p.6701-6704

1996

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Chapter 9 - Ring Transformations

The Practice of Medicinal Chemistry, 2015, p.243-266

Fourth Edition, 2015

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N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Chryso-lactams:Gold(I) derivatives of ampicillin with specific activity against Gram-positive pathogens

1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs

Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF-[kappa]B and Its Ligand

4-Hydroxy- N -[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-κB cascade

Porphyrin Derivatives Inhibit the Interaction between Receptor Activator of NF‐κB and Its Ligand

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIKElectronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, and biochemical protocols. See DOI: 10.1039/c8md00068a

N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK† †Electronic supplementary information (ESI) available: Additional biochemical data, chemistry, NMR characterization of final compounds, and biochemical protocols. See DOI: 10.1039/c8md00068a

Fragment pharmacophore-based in silico screening: a powerful approach for efficient lead discoveryThe authors declare no competing interests

Fragment pharmacophore-based in silicoscreening: a powerful approach for efficient lead discovery

Fragment pharmacophore-based in silico screening: a powerful approach for efficient lead discovery

Structural, Magnetic, and Dynamic Characterization of the (d xz ,d y z )4(d x y )1 Ground-State Low-Spin Iron(III) Tetraphenylporphyrinate Complex [(p-TTP)Fe(2,6-XylylNC)2]CF3SO3

Palladium Assisted Substitution of 3-Benzo[b]furan Triflates

Synthesis of constrained arylpiperidines using intramolecular Heck or radical reactions

Synthesis and Characterization of Low-Spin Bis(amino ester) Iron(III) Porphyrin Complexes

Oxidation of amino esters to imine complexes with chiral high-valent oxoruthenium porphyrins

Oxidation and chiral recognition of amino esters by dioxoruthenium(VI) porphyrins: Synthesis of new imino ester Ru (II) complexes

Chapter 9 - Ring Transformations

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