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Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (3), p.383-388

2019

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Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4745-4751

2005

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.360-365

2013

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Benzothiazole based inhibitors of p38α MAP kinase

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1874-1879

2008

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The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (15), p.4979-4985

2012

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Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.949-953

2006

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3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3245-3250

2004

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Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2090-2093

2019

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Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors

Bioorganic & medicinal chemistry letters, 2017-07, Vol.27 (14), p.3101-3106

2017

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Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2383-2388

2010

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Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127530, Article 127530

2020

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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.537-541

2011

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Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha

Bioorganic & medicinal chemistry letters, 2019-04, Vol.29 (7), p.905-911

2019

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Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5721-5726

2014

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Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6307-6312

2009

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Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6196-6199

2009

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Japonicones A–D, bioactive dimeric sesquiterpenes from Inula japonica Thunb

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.710-713

2009

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A new strategy to combat Alzheimer’s disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.21-24

2005

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Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′- C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (23), p.7094-7098

2011

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A theoretical investigation on DPPH radical-scavenging mechanism of edaravone

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3789-3792

2003

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Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.405-408

2008

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Substituted indanylacetic acids as PPAR-α–γ activators

Bioorganic & medicinal chemistry letters, 2006-01, Vol.16 (2), p.297-301

2006

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Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agents

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.289-292

2012

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Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4564-4569

2005

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Anion of hypericin is crucial to understanding the photosensitive features of the pigment

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1414-1417

2006

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Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Benzothiazole based inhibitors of p38α MAP kinase

The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors

Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1

Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead

Japonicones A–D, bioactive dimeric sesquiterpenes from Inula japonica Thunb

A new strategy to combat Alzheimer’s disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule

Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′- C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates

A theoretical investigation on DPPH radical-scavenging mechanism of edaravone

Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)

Substituted indanylacetic acids as PPAR-α–γ activators

Synthesis and biological evaluation of novel derivatives of gambogic acid as anti-hepatocellular carcinoma agents

Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists

Anion of hypericin is crucial to understanding the photosensitive features of the pigment

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