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A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells

Science signaling, 2024-01, Vol.17 (821), p.eadi7861

2024

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The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome

JACC. Basic to translational science, 2024-01, Vol.9 (1), p.46-62

2024

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Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3

The Journal of biological chemistry, 2023-04, Vol.299 (4), p.104584-104584, Article 104584

2023

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Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice

Journal of bone and mineral research, 2023-01, Vol.38 (1), p.171-185

2023

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Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

PNAS nexus, 2022-09, Vol.1 (4), p.pgac191-pgac191

2022

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An auto-inhibited state of protein kinase G and implications for selective activation

eLife, 2022-08, Vol.11

2022

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PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102175-102175, Article 102175

2022

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Constitutive protein kinase G activation exacerbates stress‐induced cardiomyopathy

British journal of pharmacology, 2022-06, Vol.179 (11), p.2413-2429

2022

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Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2–Driven Regulation of Nitric Oxide and Invadopodia Formation

The American journal of pathology, 2021-12, Vol.191 (12), p.2203-2218

2021

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Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

Scientific reports, 2020-11, Vol.10 (1), p.19907-19907, Article 19907

2020

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A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP

The Journal of biological chemistry, 2020-07, Vol.295 (30), p.10394-10405

2020

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Correction to: Crystal structure of PKG I[beta] holoenzyme reveals a trans-inhibiting dimer assembly

Journal of translational medicine, 2020-01, Vol.18 (1)

2020

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Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly

Journal of translational medicine, 2020-01, Vol.18 (1), p.27-27, Article 27

2020

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Letter by Casteel Regarding Article, “Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of the cGMP-Dependent Protein Kinase”

Circulation (New York, N.Y.), 2019-11, Vol.140 (22), p.e808-e809

Casteel, Darren E

2019

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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Nature communications, 2019-08, Vol.10 (1), p.1-13, Article 3533

2019

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Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B 12 analog

Nature communications, 2019-08, Vol.10 (1), p.3533

2019

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cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss

Journal of endocrinology, 2018-09, Vol.238 (3), p.203-219

2018

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Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

The Journal of biological chemistry, 2018-07, Vol.293 (28), p.10985-10992

2018

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Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

The Journal of biological chemistry, 2018-07, Vol.293 (28)

2018

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Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells

The Journal of biological chemistry, 2018-03, Vol.293 (12), p.4411-4421

2018

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The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

The Journal of biological chemistry, 2017-05, Vol.292 (20), p.8262-8268

2017

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Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase

The American journal of pathology, 2017, Vol.187 (1), p.200-213

2017

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A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice

Journal of bone and mineral research, 2017-01, Vol.32 (1), p.46-59

2017

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O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts

The Journal of biological chemistry, 2016-12, Vol.291 (51), p.26515-26528

2016

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AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2

Molecular and cellular biology, 2016-12, Vol.36 (24), p.3086-3099

2016

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A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells

The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome

Phosphatase regulatory subunit MYPT2 knockout partially compensates for the cardiac dysfunction in mice caused by lack of myosin light chain kinase 3

Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice

Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice

An auto-inhibited state of protein kinase G and implications for selective activation

PKGIα is activated by metal-dependent oxidation in vitro but not in intact cells

Constitutive protein kinase G activation exacerbates stress‐induced cardiomyopathy

Bladder Cancer Invasion Is Mediated by Mammalian Target of Rapamycin Complex 2–Driven Regulation of Nitric Oxide and Invadopodia Formation

Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP

Correction to: Crystal structure of PKG I[beta] holoenzyme reveals a trans-inhibiting dimer assembly

Correction to: Crystal structure of PKG Iβ holoenzyme reveals a trans‑inhibiting dimer assembly

Letter by Casteel Regarding Article, “Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of the cGMP-Dependent Protein Kinase”

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B 12 analog

cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss

Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

Structural basis for selective inhibition of human PKG Iα by the balanol-like compound N46

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells

The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase–Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase

A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice

O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2

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