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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

Science (American Association for the Advancement of Science), 2017-08, Vol.357 (6350), p.507-511

2017

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Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists

Nature communications, 2022-02, Vol.13 (1), p.942-15, Article 942

2022

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Glucagon receptor antagonism induces increased cholesterol absorption[S]

Journal of lipid research, 2015-11, Vol.56 (11), p.2183-2195

2015

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Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

Proceedings of the National Academy of Sciences - PNAS, 2007-09, Vol.104 (39), p.15490-15495

2007

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MB06322 (CS-917): A Potent and Selective Inhibitor of Fructose 1,6-Bisphosphatase for Controlling Gluconeogenesis in Type 2 Diabetes

Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (22), p.7970-7975

2005

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Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

Journal of the American Chemical Society, 2007-12, Vol.129 (50), p.15491-15502

2007

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Liver-targeted drug delivery using HepDirect prodrugs

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.554-560

2005

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Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats

Diabetes (New York, N.Y.), 2006-06, Vol.55 (6), p.1747-1754

2006

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Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

Antimicrobial Agents and Chemotherapy, 2011-08, Vol.55 (8), p.3854-3860

2011

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Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.153-165

2011

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Reduction of hepatic steatosis in rats and mice after treatment with a liver‐targeted thyroid hormone receptor agonist

Hepatology (Baltimore, Md.), 2009-02, Vol.49 (2), p.407-417

2009

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Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2393-2403

2008

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Using [ 2 H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies

American journal of physiology: endocrinology and metabolism, 2018-07, Vol.315 (1), p.E63-E71

2018

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Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus

American journal of physiology: endocrinology and metabolism, 2016-12, Vol.311 (6), p.E911-E921

2016

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Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice

The Journal of biological chemistry, 2016-11, Vol.291 (45), p.23428-23439

2016

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Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.666-676

2008

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Adenosine Kinase Inhibitors. 6. Synthesis, Water Solubility, and Antinociceptive Activity of 5-Phenyl-7-(5-deoxy-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines Substituted at C4 with Glycinamides and Related Compounds

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7808-7820

2005

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Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β-d-arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma

Journal of medicinal chemistry, 2006-12, Vol.49 (26), p.7711-7720

2006

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Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2883-2893

2000

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Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

Cancer chemotherapy and pharmacology, 2009-10, Vol.64 (5), p.981-991

2009

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Adenosine Kinase Inhibitors. 5. Synthesis, Enzyme Inhibition, and Analgesic Activity of Diaryl-erythro-furanosyltubercidin Analogues

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6430-6441

2005

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Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy

The Journal of pharmacology and experimental therapeutics, 1999-06, Vol.289 (3), p.1669

1999

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Pharmacologic Profile of CGS 24128, a Potent, Long-Acting Inhibitor of Neutral Endopeptidase 24.11

Journal of cardiovascular pharmacology, 1994-03, Vol.23 (3), p.358-364

1994

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Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver

Journal of the American Chemical Society, 2004-04, Vol.126 (16), p.5154-5163

2004

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pH- and time-dependent inhibition of rat kidney neutral endoprotease 24.11 by thiorphan and phosphoramidon

Life sciences (1973), 1989, Vol.45 (22), p.2109-2114

1989

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists

Glucagon receptor antagonism induces increased cholesterol absorption[S]

Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

MB06322 (CS-917): A Potent and Selective Inhibitor of Fructose 1,6-Bisphosphatase for Controlling Gluconeogenesis in Type 2 Diabetes

Discovery of Potent and Specific Fructose-1,6-Bisphosphatase Inhibitors and a Series of Orally-Bioavailable Phosphoramidase-Sensitive Prodrugs for the Treatment of Type 2 Diabetes

Liver-targeted drug delivery using HepDirect prodrugs

Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats

Antiviral Efficacy upon Administration of a HepDirect Prodrug of 2′-C-Methylcytidine to Hepatitis C Virus-Infected Chimpanzees

Discovery of a Series of Phosphonic Acid-Containing Thiazoles and Orally Bioavailable Diamide Prodrugs That Lower Glucose in Diabetic Animals Through Inhibition of Fructose-1,6-Bisphosphatase

Reduction of hepatic steatosis in rats and mice after treatment with a liver‐targeted thyroid hormone receptor agonist

Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist

Using [ 2 H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies

Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus

Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice

Pradefovir: A Prodrug That Targets Adefovir to the Liver for the Treatment of Hepatitis B

Adenosine Kinase Inhibitors. 6. Synthesis, Water Solubility, and Antinociceptive Activity of 5-Phenyl-7-(5-deoxy-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines Substituted at C4 with Glycinamides and Related Compounds

Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β-d-arabinofuranoside Monophosphate for the Treatment of Hepatocellular Carcinoma

Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

Adenosine Kinase Inhibitors. 5. Synthesis, Enzyme Inhibition, and Analgesic Activity of Diaryl-erythro-furanosyltubercidin Analogues

Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy

Pharmacologic Profile of CGS 24128, a Potent, Long-Acting Inhibitor of Neutral Endopeptidase 24.11

Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver

pH- and time-dependent inhibition of rat kidney neutral endoprotease 24.11 by thiorphan and phosphoramidon

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