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Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

Clinical cancer research, 2018-06, Vol.24 (11), p.2631-2641

2018

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Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

Investigational new drugs, 2020-12, Vol.38 (6), p.1796-1806

2020

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Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

CPT: pharmacometrics and systems pharmacology, 2021-11, Vol.10 (11), p.1396-1411

2021

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Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

Clinical and translational science, 2024-03, Vol.17 (3), p.e13756-n/a

2024

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Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

Clinical pharmacology and therapeutics, 2021-06, Vol.109 (6), p.1618-1630

2021

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Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions

European journal of pharmaceutical sciences, 2021-10, Vol.165, p.105932-105932, Article 105932

2021

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Development of a physiologically-based pharmacokinetic model of the rat central nervous system

Pharmaceutics, 2014-03, Vol.6 (1), p.97-136

2014

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Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials

Drug discovery today, 2023-07, Vol.28 (7), p.103605-103605, Article 103605

2023

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How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example

Clinical pharmacology and therapeutics, 2023-02, Vol.113 (2), p.310-320

2023

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Pharmacokinetic Modeling of Free Amoxicillin Concentrations in Rat Muscle Extracellular Fluids Determined by Microdialysis

Antimicrobial Agents and Chemotherapy, 2005-09, Vol.49 (9), p.3702-3706

2005

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Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

European journal of pharmaceutical sciences, 2017-08, Vol.106, p.122-132

2017

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Impact of interleukin‐6 on drug transporters and permeability in the hCMEC/D3 blood–brain barrier model

Fundamental & clinical pharmacology, 2021-04, Vol.35 (2), p.397-409

2021

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Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

Clinical pharmacology and therapeutics, 2021-03, Vol.109 (3), p.605-618

2021

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Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration

Antimicrobial Agents and Chemotherapy, 2006-01, Vol.50 (1), p.371-373

2006

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Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

Drug metabolism and disposition, 2019-06, Vol.47 (6), p.648-656

2019

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Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Clinical pharmacology and therapeutics, 2018-03, Vol.103 (3), p.378-383

2018

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Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development

Clinical pharmacology and therapeutics, 2020-06, Vol.107 (6), p.1285-1289

2020

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PA-298 Predicting disease effect on the pharmacokinetics (PK) of sustained and immediate release formulations by applying physiologically based pharmacokinetic (PBPK) modelling

BMJ global health, 2023-12, Vol.8 (Suppl 10), p.A60-A61

2023

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Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling: Two Cytochrome P450 3A4 Substrates Coadministered with Ketoconazole or Verapamil

Clinical pharmacokinetics, 2010-04, Vol.49 (4), p.239-258

2010

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Optimal Sampling Times for a Drug and its Metabolite using SIMCYP® Simulations as Prior Information

Clinical pharmacokinetics, 2013, Vol.52 (1), p.43-57

2013

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Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia

Cancer research communications, 2022-11, Vol.2 (11), p.1532-1544

2022

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Two-stage Adaptive Designs in Nonlinear Mixed Effects Models: Application to Pharmacokinetics in Children

Communications in Statistics - Simulation and Computation, 2016-05, Vol.45 (5), p.1511-1525

2016

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Comparison of nonlinear mixed effects models and non-compartmental approaches in detecting pharmacogenetic covariates: Approaches to detect pharmacogenetic covariates

The AAPS journal, 2015-02, Vol.17 (3), p.597-608

2015

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Norfloxacin-Induced Electroencephalogram Alteration and Seizures in Rats Are Not Triggered by Enhanced Levels of Intracerebral Glutamate

Antimicrobial Agents and Chemotherapy, 2003-11, Vol.47 (11), p.3660-3662

2003

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Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I

European journal of cancer (1990), 2013-09, Vol.49 (13), p.2791-2797

2013

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Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions

Development of a physiologically-based pharmacokinetic model of the rat central nervous system

Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials

How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example

Pharmacokinetic Modeling of Free Amoxicillin Concentrations in Rat Muscle Extracellular Fluids Determined by Microdialysis

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Impact of interleukin‐6 on drug transporters and permeability in the hCMEC/D3 blood–brain barrier model

Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development

PA-298 Predicting disease effect on the pharmacokinetics (PK) of sustained and immediate release formulations by applying physiologically based pharmacokinetic (PBPK) modelling

Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling: Two Cytochrome P450 3A4 Substrates Coadministered with Ketoconazole or Verapamil

Optimal Sampling Times for a Drug and its Metabolite using SIMCYP® Simulations as Prior Information

Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia

Two-stage Adaptive Designs in Nonlinear Mixed Effects Models: Application to Pharmacokinetics in Children

Comparison of nonlinear mixed effects models and non-compartmental approaches in detecting pharmacogenetic covariates: Approaches to detect pharmacogenetic covariates

Norfloxacin-Induced Electroencephalogram Alteration and Seizures in Rats Are Not Triggered by Enhanced Levels of Intracerebral Glutamate

Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I

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