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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Nature (London), 2016-09, Vol.537 (7619), p.214

2016

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Late-stage oxidative C(sp 3 )-H methylation

Nature (London), 2020-04, Vol.580 (7805), p.621

2020

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Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Journal of the American Chemical Society, 2023-01, Vol.145 (1), p.537-550

2023

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Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

Biotechnology journal, 2021-04, Vol.16 (4), p.e2000315-n/a

2021

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Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Organic process research & development, 2022-03, Vol.26 (3), p.616-623

2022

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Tetrahedron letters, 2013-12, Vol.54 (51), p.7065-7068

2013

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Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Journal of organic chemistry, 2012-11, Vol.77 (22), p.10050-10057

2012

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Novel and selective spiroindoline-based inhibitors of sky kinase

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.190-193

2012

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Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1948-1952

2011

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Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1051-1055

2013

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Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1046-1050

2013

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Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro

Chemical research in toxicology, 2011-02, Vol.24 (2), p.269-278

2011

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The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Chemical biology & drug design, 2007-08, Vol.70 (2), p.100-112

2007

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Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2501-2511

2009

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Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5567-5572

2007

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Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

Organic process research & development, 2023-05, Vol.27 (5), p.854-865

2023

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The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.1060-1064

2006

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The discovery of glycine and related amino acid-based factor Xa inhibitors

Bioorganic & medicinal chemistry, 2006-07, Vol.14 (13), p.4379-4392

2006

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The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4752-4756

2005

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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Organic process research & development, 2021-06, Vol.25 (6), p.1440-1453

2021

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Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

Chemical biology & drug design, 2007-06, Vol.69 (6), p.444-450

2007

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Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Journal of organic chemistry, 1998-07, Vol.63 (15), p.5088-5093

1998

Volltextzugriff (PDF)

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5410-5414

2013

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A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

Tetrahedron letters, 2006-10, Vol.47 (44), p.7677-7680

2006

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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Late-stage oxidative C(sp 3 )-H methylation

Enantioselective Single and Dual α‑C–H Bond Functionalization of Cyclic Amines via Enzymatic Carbene Transfer

Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Expedient synthesis of novel β-ketoesters from the Mizoroki–Heck coupling of ethyl 3-ethoxyacrylate with aryl and pyridyl halides

Synthesis of Spiropiperidine Lactam Acetyl-CoA Carboxylase Inhibitors

Novel and selective spiroindoline-based inhibitors of sky kinase

Activation of the G-Protein-Coupled Receptor 119: A Conformation-Based Hypothesis for Understanding Agonist Response

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

Intrinsic Electrophilicity of a 4-Substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine Derivative: Structural Characterization of Glutathione Conjugates in Vitro

The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor

Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action

Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture

The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex—Part 2

The discovery of glycine and related amino acid-based factor Xa inhibitors

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex

Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors

Structure-based Drug Design of Pyrrolidine-1, 2-dicarboxamides as a Novel Series of Orally Bioavailable Factor Xa Inhibitors

Highly Functionalized Cyclohexenyl Systems: Enzymatic Resolution and Selective Oxirane Opening Reactions of p-Benzoquinone Derivatives

Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor

A versatile copper-catalyzed coupling reaction of pyridin-2(1 H)-ones with aryl halides

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