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Gordon Syndrome: a continuing story

Pediatric Nephrology, 2015-11, Vol.30 (11), p.1903-1908

O’Shaughnessy, Kevin M.

2015

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Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas

Hypertension (Dallas, Tex. 1979), 2012-03, Vol.59 (3), p.587-591

2012

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Role for Germline Mutations and a Rare Coding Single Nucleotide Polymorphism Within the KCNJ5 Potassium Channel in a Large Cohort of Sporadic Cases of Primary Aldosteronism

Hypertension (Dallas, Tex. 1979), 2014-04, Vol.63 (4), p.783-789

2014

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Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success

The Journal of experimental medicine, 2004-10, Vol.200 (8), p.957-965

2004

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Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma

Journal of hypertension, 2012-09, Vol.30 (9), p.1827-1833

2012

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Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels

Clinical science (1979), 2018-01, Vol.132 (1), p.145-156

2018

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Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells

Molecular endocrinology (Baltimore, Md.), 2015-10, Vol.29 (10), p.1522-1530

2015

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Genetics of arterial structure and function: towards new biomarkers for aortic stiffness?

Clinical science (1979), 2008-06, Vol.114 (11), p.661-677

2008

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Renal and Brain Isoforms of WNK3 Have Opposite Effects on NCCT Expression

Journal of the American Society of Nephrology, 2009-06, Vol.20 (6), p.1314-1322

2009

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Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals

Arteriosclerosis, thrombosis, and vascular biology, 2006-08, Vol.26 (8), p.1799-1805

2006

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Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study

Medicine (Baltimore), 2021-04, Vol.100 (14), p.e24654-e24654

2021

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The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4

Canadian journal of physiology and pharmacology, 2010-10, Vol.88 (10), p.986-995

2010

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A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression

European journal of human genetics : EJHG, 2016-01, Vol.25 (1), p.157-160

2016

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WNK1 affects surface expression of the ROMK potassium channel independent of WNK4

Journal of the American Society of Nephrology, 2006-07, Vol.17 (7), p.1867-1874

2006

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Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved

American journal of physiology. Renal physiology, 2006-12, Vol.291 (6), p.F1369-F1376

2006

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A New Kindred With Pseudohypoaldosteronism Type II and a Novel Mutation (564D>H) in the Acidic Motif of the WNK4 Gene

Hypertension (Dallas, Tex. 1979), 2005-08, Vol.46 (2), p.295-300

2005

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The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK

Biochemical and biophysical research communications, 2008-10, Vol.375 (4), p.651-654

2008

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The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

Scientific reports, 2018-06, Vol.8 (1), p.8550-16, Article 8550

2018

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HapMap, pharmacogenomics, and the goal of personalized prescribing

British journal of clinical pharmacology, 2006-06, Vol.61 (6), p.783-786

O’Shaughnessy, Kevin M.

2006

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Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia

The Journal of clinical investigation, 2017-09, Vol.127 (9), p.3367-3374

2017

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Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia

Clinical and experimental pharmacology & physiology, 2013-12, Vol.40 (12), p.876-884

2013

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Extrarenal roles of the with-no-lysine[K] kinases (WNKs)

Clinical and experimental pharmacology & physiology, 2013-12, Vol.40 (12), p.885-894

2013

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A systematic review and meta‐analysis of thiazide‐induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?

British journal of clinical pharmacology, 2015-04, Vol.79 (4), p.566-577

2015

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The genetics of essential hypertension

British journal of clinical pharmacology, 2001-01, Vol.51 (1), p.5-11

O'Shaughnessy, Kevin M.

2001

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Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion

American journal of physiology: endocrinology and metabolism, 2008-12, Vol.295 (6), p.E1480-E1486

2008

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Gordon Syndrome: a continuing story

Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas

Role for Germline Mutations and a Rare Coding Single Nucleotide Polymorphism Within the KCNJ5 Potassium Channel in a Large Cohort of Sporadic Cases of Primary Aldosteronism

Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success

Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma

Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels

Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells

Genetics of arterial structure and function: towards new biomarkers for aortic stiffness?

Renal and Brain Isoforms of WNK3 Have Opposite Effects on NCCT Expression

Variation in the human matrix metalloproteinase-9 gene is associated with arterial stiffness in healthy individuals

Nonadherence to antihypertensive medications amongst patients with uncontrolled hypertension: A retrospective study

The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4

A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression

WNK1 affects surface expression of the ROMK potassium channel independent of WNK4

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved

A New Kindred With Pseudohypoaldosteronism Type II and a Novel Mutation (564D>H) in the Acidic Motif of the WNK4 Gene

The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK

The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness

HapMap, pharmacogenomics, and the goal of personalized prescribing

Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia

Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia

Extrarenal roles of the with-no-lysine[K] kinases (WNKs)

A systematic review and meta‐analysis of thiazide‐induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?

The genetics of essential hypertension

Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion

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