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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain

Acta neuropathologica, 2021-06, Vol.141 (6), p.823-839

2021

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Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

Nature reviews. Drug discovery, 2012-04, Vol.11 (4), p.292-310

2012

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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules

European journal of medicinal chemistry, 2022-10, Vol.240, p.114578-114578, Article 114578

2022

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NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

Hypertension (Dallas, Tex. 1979), 2019-06, Vol.73 (6), p.1300-1307

2019

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Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

The FASEB journal, 2012-12, Vol.26 (12), p.5161-5171

2012

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Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Clinical pharmacokinetics, 2014-04, Vol.53 (4), p.385-395

2014

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Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2012-08, Vol.60 (2), p.411-418

2012

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New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5748-5763

2014

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Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain

European journal of pharmacology, 2016-10, Vol.788, p.176-182

2016

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Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

The Journal of neuroscience, 2014-01, Vol.34 (3), p.1057-1066

2014

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Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell–Mediated Relaxations of Bovine Adrenal Cortical Arteries

Endocrinology (Philadelphia), 2018-01, Vol.159 (1), p.238-247

2018

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TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions

The Journal of neuroscience, 2014-04, Vol.34 (15), p.5385-5395

2014

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Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

Journal of neurochemistry, 2009-04, Vol.109 (1), p.248-256

2009

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Structure-function relationship of Vpr: biological implications

Current HIV research, 2009-03, Vol.7 (2), p.184-210

2009

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Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure: A New Strategy for Treating Hypertension

Hypertension (Dallas, Tex. 1979), 2008-05, Vol.51 (5), p.1318-1325

2008

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How the HIV-1 Nucleocapsid Protein Binds and Destabilises the (−)Primer Binding Site During Reverse Transcription

Journal of molecular biology, 2008-11, Vol.383 (5), p.1112-1128

2008

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Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

Neuropsychopharmacology (New York, N.Y.), 2012-01, Vol.37 (1), p.303-304

2012

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Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

Hypertension (Dallas, Tex. 1979), 2008-02, Vol.51 (2, part 2), p.460-465

2008

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Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs

Expert opinion on therapeutic targets, 2007-02, Vol.11 (2), p.145-159

2007

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Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Nature (London), 2000-02, Vol.403 (6772), p.916-921

2000

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Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice

Science (American Association for the Advancement of Science), 1999-01, Vol.283 (5400), p.401-404

1999

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Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3883-3890

2017

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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Nature (London), 1997-08, Vol.388 (6642), p.586-589

1997

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Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (20), p.7775-7780

2004

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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain

Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules

NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue

Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain

Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum

Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell–Mediated Relaxations of Bovine Adrenal Cortical Arteries

TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions

Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide

Structure-function relationship of Vpr: biological implications

Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure: A New Strategy for Treating Hypertension

How the HIV-1 Nucleocapsid Protein Binds and Destabilises the (−)Primer Binding Site During Reverse Transcription

Endogenous Opioids as Physiological Antidepressants: Complementary Role of Delta Receptors and Dopamine

Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats

Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice

Substituted α-mercaptoketones, new types of specific neprilysin inhibitors

Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Brain Renin-Angiotensin System Blockade by Systemically Active Aminopeptidase A Inhibitors: A Potential Treatment of Salt-Dependent Hypertension

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