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Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

Free radical biology & medicine, 2015-11, Vol.88 (Pt B), p.253-267

2015

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Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

Biochimica et biophysica acta, 2014-08, Vol.1842 (8), p.1208-1218

2014

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The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases

Recent patents on CNS drug discovery, 2012-12, Vol.7 (3), p.218-229

2012

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Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model

The Journal of neuroscience, 2012-12, Vol.32 (49), p.17775-17787

2012

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Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

The Journal of neuroscience, 2008-12, Vol.28 (50), p.13574-13581

2008

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Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Nature communications, 2022-01, Vol.13 (1), p.135-135, Article 135

2022

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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (8), p.2933-2938

2009

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The Nrf2–ARE cytoprotective pathway in astrocytes

Expert reviews in molecular medicine, 2009-06, Vol.11, p.e17-e17, Article e17

2009

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The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

Toxicological sciences, 2010-04, Vol.114 (2), p.237-246

2010

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Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

Neurotoxicology (Park Forest South), 2012-06, Vol.33 (3), p.272-279

2012

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Astrogliosis in Amyotrophic Lateral Sclerosis: Role and Therapeutic Potential of Astrocytes

Neurotherapeutics, 2010-10, Vol.7 (4), p.471-481

2010

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Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Nature communications, 2023-06, Vol.14 (1), p.3372-3372, Article 3372

2023

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Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury

Neurobiology of disease, 2013-06, Vol.54, p.329-338

2013

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Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

Scientific reports, 2018-08, Vol.8 (1), p.12552-14, Article 12552

2018

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Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

Genes & development, 2010-05, Vol.24 (10), p.1045-1058

2010

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Mechanisms of Nrf2 protection in astrocytes as identified by quantitative proteomics and siRNA screening

PloS one, 2013-07, Vol.8 (7), p.e70163

2013

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Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human

Antioxidants & redox signaling, 2014-01, Vol.20 (1), p.15-30

2014

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An important role of Nrf2-ARE pathway in the cellular defense mechanism

BMB reports, 2004-03, Vol.37 (2), p.139-143

2004

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The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

Journal of neuroinflammation, 2011-08, Vol.8 (1), p.91-91, Article 91

2011

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Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

The Journal of biological chemistry, 2003-04, Vol.278 (14), p.12029-12038

2003

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Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir

PLoS medicine, 2008-02, Vol.5 (2), p.291-299

2008

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Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

The Journal of neuroscience, 2003-04, Vol.23 (8), p.3394-3406

2003

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Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression

The Journal of neuroscience, 2011-05, Vol.31 (20), p.7392-7401

2011

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Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models

PloS one, 2013-02, Vol.8 (2), p.e56625-e56625

2013

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Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

Molecular cancer therapeutics, 2007-01, Vol.6 (1), p.154-162

2007

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Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases

Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

The Nrf2–ARE cytoprotective pathway in astrocytes

The Absence of the Pro-antioxidant Transcription Factor Nrf2 Exacerbates Experimental Autoimmune Encephalomyelitis

Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

Astrogliosis in Amyotrophic Lateral Sclerosis: Role and Therapeutic Potential of Astrocytes

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury

Astrocyte-specific overexpression of Nrf2 protects against optic tract damage and behavioural alterations in a mouse model of cerebral hypoperfusion

Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis

Mechanisms of Nrf2 protection in astrocytes as identified by quantitative proteomics and siRNA screening

Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human

An important role of Nrf2-ARE pathway in the cellular defense mechanism

The PPAR-γ agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys

Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression

Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

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