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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

The Journal of biological chemistry, 2024-04, Vol.300 (4), p.107155-107155, Article 107155

2024

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Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

Scientific reports, 2024-05, Vol.14 (1), p.11105-11105

2024

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Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Canadian journal of physiology and pharmacology, 2023-01, Vol.101 (1), p.41

2023

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A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels

Journal of ethnopharmacology, 2024-08, Vol.330, p.118218-118218, Article 118218

2024

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Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

The Journal of general physiology, 2019-02, Vol.151 (2), p.214-230

2019

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Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

Journal of chemical information and modeling, 2023-05, Vol.63 (10), p.3043-3053

2023

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

Pharmacology & therapeutics (Oxford), 2006-07, Vol.111 (1), p.224-259

2006

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KATP Channels in the Cardiovascular System

Physiological reviews, 2016-01, Vol.96 (1), p.177-252

2016

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Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.5916

2015

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Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

Science (American Association for the Advancement of Science), 2009-12, Vol.326 (5960), p.1668-1674

2009

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Purlisin, a toxin‐like defensin derived from clinical pathogenic fungus Purpureocillium lilacinum with both antimicrobial and potassium channel inhibitory activities

The FASEB journal, 2020-11, Vol.34 (11), p.15093-15107

2020

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Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy

Biomedicine & pharmacotherapy, 2024-06, Vol.175, p.116651-116651, Article 116651

2024

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Blocking the Passage: C60 Geometrically Clogs K+ Channels

ACS nano, 2015-05, Vol.9 (5), p.4827-4834

2015

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Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels

The Journal of membrane biology, 2023-02, Vol.256 (1), p.63-77

2023

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Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel

Amino acids, 2019-02, Vol.51 (2), p.355

2019

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Mechanisms of gefitinib-induced QT prolongation

European journal of pharmacology, 2021-11, Vol.910, p.174441-174441, Article 174441

2021

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Isolation and structural identification of a potassium ion channel Kv4.1 inhibitor SsTx-P2 from centipede venom

Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2024-04, Vol.53 (2), p.194

2024

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Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

eLife, 2018-11, Vol.7

2018

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Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

Hypertension (Dallas, Tex. 1979), 2011-06, Vol.57 (6), p.1129-1135

2011

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Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability

Journal of neurophysiology, 2016-08, Vol.116 (2), p.456-465

2016

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K V 7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure

American journal of physiology. Renal physiology, 2022-02, Vol.322 (2), p.F197-F207

2022

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Repurposing the K Ca 3.1 Blocker Senicapoc for Ischemic Stroke

Translational stroke research, 2024-06, Vol.15 (3), p.518

2024

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Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

The Journal of biological chemistry, 2014-05, Vol.289 (18), p.12623-12632

2014

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Corelease of acetylcholine and GABA from cholinergic forebrain neurons

eLife, 2015-02, Vol.4

2015

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1 – 25 von 15.198

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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

KATP Channels in the Cardiovascular System

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

Purlisin, a toxin‐like defensin derived from clinical pathogenic fungus Purpureocillium lilacinum with both antimicrobial and potassium channel inhibitory activities

Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy

Blocking the Passage: C60 Geometrically Clogs K+ Channels

Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels

Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel

Mechanisms of gefitinib-induced QT prolongation

Isolation and structural identification of a potassium ion channel Kv4.1 inhibitor SsTx-P2 from centipede venom

Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability

K V 7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure

Repurposing the K Ca 3.1 Blocker Senicapoc for Ischemic Stroke

Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

Corelease of acetylcholine and GABA from cholinergic forebrain neurons

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