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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

Science (American Association for the Advancement of Science), 2021-01, Vol.371 (6527), p.405-410

2021

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PI3Kγ is a molecular switch that controls immune suppression

Nature (London), 2016-11, Vol.539 (7629), p.437-442

2016

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Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Science (American Association for the Advancement of Science), 2019-11, Vol.366 (6466), p.714-723

2019

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Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Proceedings of the National Academy of Sciences - PNAS, 2016-07, Vol.113 (30), p.E4338-E4347

2016

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Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

Nature communications, 2015-01, Vol.6 (1), p.5937-5937, Article 5937

2015

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Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Molecular and cellular endocrinology, 2017-09, Vol.452, p.44-56

2017

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Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Gastroenterology (New York, N.Y. 1943), 2015-12, Vol.149 (7), p.1884-1895.e4

2015

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Vascular endothelial growth factor receptor-3 directly interacts with phosphatidylinositol 3-kinase to regulate lymphangiogenesis

PloS one, 2012-06, Vol.7 (6), p.e39558-e39558

2012

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The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12), p.2269-2280

2022

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MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

Scientific reports, 2017-09, Vol.7 (1), p.11313-15, Article 11313

2017

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The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25

Asian Pacific journal of cancer prevention : APJCP, 2019-11, Vol.20 (11), p.3377-3383

2019

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Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling

Blood, 2012-01, Vol.119 (3), p.847-856

2012

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Maximising the potential of AKT inhibitors as anti-cancer treatments

Pharmacology & therapeutics (Oxford), 2017-04, Vol.172, p.101-115

2017

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Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis

PloS one, 2012-09, Vol.7 (9), p.e45427-e45427

2012

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Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Scientific reports, 2022-04, Vol.12 (1), p.5924-5924, Article 5924

2022

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PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (39), p.24427-24433

2020

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The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Scientific reports, 2019-08, Vol.9 (1), p.11317-12, Article 11317

2019

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Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.18862-18867

2013

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Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Bioengineered, 2022-05, Vol.13 (5), p.12625-12636

2022

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Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (37)

2021

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PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway

Blood, 2024-05, Vol.143 (19), p.1965

2024

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Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (37), p.15043-15048

2013

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LncRNA AK023948 is a positive regulator of AKT

Nature communications, 2017-02, Vol.8 (1), p.14422-10, Article 14422

2017

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Report of a Chinese Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome

Journal of clinical immunology, 2018-11, Vol.38 (8), p.854-863

2018

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PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

PI3Kγ is a molecular switch that controls immune suppression

Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

Vascular endothelial growth factor receptor-3 directly interacts with phosphatidylinositol 3-kinase to regulate lymphangiogenesis

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

The Role of the LY294002 - A Non-Selective Inhibitor of Phosphatidylinositol 3-Kinase (PI3K) Pathway- in Cell Survival and Proliferation in Cell Line SCC-25

Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling

Maximising the potential of AKT inhibitors as anti-cancer treatments

Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-α inhibition

The interleukin-33-mediated inhibition of expression of two key genes implicated in atherosclerosis in human macrophages requires MAP kinase, phosphoinositide 3-kinase and nuclear factor-κB signaling pathways

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Gastrodin protects retinal ganglion cells from ischemic injury by activating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 (PI3K/AKT/Nrf2) signaling pathway

Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases

PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway

Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer

LncRNA AK023948 is a positive regulator of AKT

Report of a Chinese Cohort with Activated Phosphoinositide 3-Kinase δ Syndrome

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