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Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Antimicrobial agents and chemotherapy, 2018-04, Vol.62 (4)

2018

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Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Antimicrobial agents and chemotherapy, 2016-05, Vol.60 (5), p.3115-3118

2016

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JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium

Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.170-177

2015

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Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo

PLoS neglected tropical diseases, 2008-03, Vol.2 (3), p.e190

2008

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X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy

The Journal of biological chemistry, 2007-08, Vol.282 (35), p.25436-25444

2007

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Novel diaryl ureas with efficacy in a mouse model of malaria

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (4), p.1022-1025

2013

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Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5247-5252

2005

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Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2163-2169

2006

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Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

Antimicrobial Agents and Chemotherapy, 2005-08, Vol.49 (8), p.3463-3467

2005

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Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines

Drug metabolism and disposition, 2008-02, Vol.36 (2), p.380-385

2008

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In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines

Journal of medicinal chemistry, 2005-04, Vol.48 (8), p.2805-2813

2005

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Identification of the optimal third generation antifolate against P. falciparum and P. vivax

Molecular and biochemical parasitology, 2005-12, Vol.144 (2), p.198-205

2005

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Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate—JPC2056—in cynomolgus monkeys using an in vivo–in vitro model

Journal of antimicrobial chemotherapy, 2007-10, Vol.60 (4), p.811-818

2007

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Analysis of the Energetics of Gas-Phase Immunophilin-Ligand Complexes by Ion Spray Mass Spectrometry

Journal of the American Chemical Society, 1994-08, Vol.116 (17), p.7487-7493

1994

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The structure of leptosphaerin

Tetrahedron letters, 1986, Vol.27 (46), p.5587-5590

1986

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Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 5247–5252]

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3618-3619

2006

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Patent Update: Anti-inflammatory Patent Highlights from the Second Half of 1992

Current Opinion on Therapeutic Patents, 1993-05, Vol.3 (5), p.513-543

1993

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Total synthesis of (.+-.)-9-pupukeanone

Journal of organic chemistry, 1980-05, Vol.45 (10), p.1864-1868

1980

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Structure, Sythesis and Absolute Configuration of Leptosphaerin, a Metabolite of the Marine Ascomycete Leptosphaeria oraemaris

Tetrahedron, 1989, Vol.45 (21), p.6631-6644

1989

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Syntheses and gastric acid antisecretory properties of the H2-receptor antagonist N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]thieno[3,4-d]isothiazol-3-amine 1,1-dioxide and related derivatives

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1480-1486

1988

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Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents

Journal of medicinal chemistry, 1989-05, Vol.32 (5), p.1024-1033

1989

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THE ISOLATION AND STRUCTURE OF LEPTOSPHAERIN: A METABOLITE OF THE MARINE ASCOMYCETE, LEPTOSPHAERIA ORAEMARIS (LINDER) AND A SYNTHESIS OF THE MARINE TOXIN, 9-ISOCYANOPUPUKEANANE

SCHIEHSER, GUY ALAN

1980

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Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

Lead Selection of a New Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention

JPC-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of Plasmodium

Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo

X-ray Structural Analysis of Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase as a Pathway toward the Optimization of Triclosan Antimalarial Efficacy

Novel diaryl ureas with efficacy in a mouse model of malaria

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines

In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines

Identification of the optimal third generation antifolate against P. falciparum and P. vivax

Antimalarial pharmacodynamics and pharmacokinetics of a third-generation antifolate—JPC2056—in cynomolgus monkeys using an in vivo–in vitro model

The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites

Analysis of the Energetics of Gas-Phase Immunophilin-Ligand Complexes by Ion Spray Mass Spectrometry

The structure of leptosphaerin

Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 5247–5252]

Patent Update: Anti-inflammatory Patent Highlights from the Second Half of 1992

Total synthesis of (.+-.)-9-pupukeanone

Structure, Sythesis and Absolute Configuration of Leptosphaerin, a Metabolite of the Marine Ascomycete Leptosphaeria oraemaris

Syntheses and gastric acid antisecretory properties of the H2-receptor antagonist N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]thieno[3,4-d]isothiazol-3-amine 1,1-dioxide and related derivatives

Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents

THE ISOLATION AND STRUCTURE OF LEPTOSPHAERIN: A METABOLITE OF THE MARINE ASCOMYCETE, LEPTOSPHAERIA ORAEMARIS (LINDER) AND A SYNTHESIS OF THE MARINE TOXIN, 9-ISOCYANOPUPUKEANANE

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