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Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation

Bioorganic & medicinal chemistry letters, 2024-07, Vol.107, p.129778-129778, Article 129778

2024

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Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites

Analytica chimica acta, 2024-07, Vol.1312, p.342755-342755, Article 342755

2024

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The impact of E3 ligase choice on PROTAC effectiveness in protein kinase degradation

Drug discovery today, 2024-07, Vol.29 (7), p.104032, Article 104032

2024

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Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy

International journal of nanomedicine, 2024-06, Vol.19, p.5739-5761

2024

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Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain

Developmental cell, 2024-06, Vol.59 (11), p.1425-1438.e8

2024

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Discovery of a potent Gilteritinib-based FLT3-PROTAC degrader for the treatment of Acute myeloid leukemia

Bioorganic chemistry, 2024-08, Vol.149, p.107477, Article 107477

2024

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Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

Neurobiology of disease, 2024-09, Vol.199, p.106556, Article 106556

2024

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Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7301-7311

2024

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PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer

Pharmacological research, 2024-07, Vol.205, p.107234, Article 107234

2024

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PA28γ, the ring that makes tumors invisible to the immune system?

Biochimie, 2024-04

Cascio, Paolo

2024

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Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey

Biochimie, 2024-04

2024

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Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

Journal of medicinal chemistry, 2024-05, Vol.67 (9), p.7283-7300

2024

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A review on structure-function mechanism and signaling pathway of serine/threonine protein PIM kinases as a therapeutic target

International journal of biological macromolecules, 2024-06, Vol.270 (Pt 1), p.132030-132030, Article 132030

2024

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CDK9 targeting PROTAC L055 inhibits ERα-positive breast cancer

Biomedicine & pharmacotherapy, 2024-08, Vol.177, p.116972, Article 116972

2024

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Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins

European journal of medicinal chemistry, 2024-06, Vol.272, p.116489-116489, Article 116489

2024

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Research progress of PROTACs for neurodegenerative diseases therapy

Bioorganic chemistry, 2024-06, Vol.147, p.107386-107386, Article 107386

2024

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Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

Developmental cell, 2024-06, Vol.59 (12), p.1571-1592.e9

2024

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PROTAC induces HIV-1 Nef degradation

Nature reviews. Drug discovery, 2024-05, Vol.23 (5), p.340-340

Crunkhorn, Sarah

2024

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Applications of protein ubiquitylation and deubiquitylation in drug discovery

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107264-107264, Article 107264

2024

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Hijacking monopolar spindle 1 (MPS1) for various cancer types by small molecular inhibitors: Deep insights from a decade of research and patents

European journal of medicinal chemistry, 2024-07, Vol.273, p.116504-116504, Article 116504

2024

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Comparative assessment of radical scavenging potential of A1 and A2 cow's milk casein pre- and post-enzymatic hydrolysis

Food science & technology, 2024-04, Vol.198, p.116038, Article 116038

2024

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A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

ACS chemical biology, 2024-05, Vol.19 (5), p.1161-1168

2024

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Small molecule induced STING degradation facilitated by the HECT ligase HERC4

Nature communications, 2024-05, Vol.15 (1), p.4584-16, Article 4584

2024

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Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia

Bioorganic chemistry, 2024-06, Vol.147, p.107319-107319, Article 107319

2024

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Expanding the ligand spaces for E3 ligases for the design of protein degraders

Bioorganic & medicinal chemistry, 2024-05, Vol.105, p.117718-117718, Article 117718

2024

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Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation

Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites

The impact of E3 ligase choice on PROTAC effectiveness in protein kinase degradation

Nano-Proteolysis Targeting Chimeras (Nano-PROTACs) in Cancer Therapy

Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain

Discovery of a potent Gilteritinib-based FLT3-PROTAC degrader for the treatment of Acute myeloid leukemia

Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

PROTACs targeting androgen receptor signaling: Potential therapeutic agents for castration-resistant prostate cancer

PA28γ, the ring that makes tumors invisible to the immune system?

Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey

Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation

A review on structure-function mechanism and signaling pathway of serine/threonine protein PIM kinases as a therapeutic target

CDK9 targeting PROTAC L055 inhibits ERα-positive breast cancer

Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins

Research progress of PROTACs for neurodegenerative diseases therapy

Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites

PROTAC induces HIV-1 Nef degradation

Applications of protein ubiquitylation and deubiquitylation in drug discovery

Hijacking monopolar spindle 1 (MPS1) for various cancer types by small molecular inhibitors: Deep insights from a decade of research and patents

Comparative assessment of radical scavenging potential of A1 and A2 cow's milk casein pre- and post-enzymatic hydrolysis

A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

Small molecule induced STING degradation facilitated by the HECT ligase HERC4

Discovery of novel co-degradation CK1α and CDK7/9 PROTACs with p53 activation for treating acute myeloid leukemia

Expanding the ligand spaces for E3 ligases for the design of protein degraders

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