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Optimization of isochromanone based urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (13), p.4844-4854

2010

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Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1540-1545

2009

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Design, parallel synthesis and SAR of novel urotensin II receptor agonists

European journal of medicinal chemistry, 2007-02, Vol.42 (2), p.276-285

2007

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Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Journal of medicinal chemistry, 1999-04, Vol.42 (7), p.1115-1122

1999

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Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2232-2240

2006

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8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist

Journal of medicinal chemistry, 1981-08, Vol.24 (8), p.921-923

1981

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3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Journal of medicinal chemistry, 1995-02, Vol.38 (3), p.473-487

1995

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Isochromanone-based urotensin-II receptor agonists

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (8), p.3057-3068

2005

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Novel and potent small-molecule urotensin II receptor agonists

Bioorganic & medicinal chemistry, 2009-07, Vol.17 (13), p.4657-4665

2009

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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4950-4953

2002

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Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7517-7519

2005

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Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin

Journal of medicinal chemistry, 1990-10, Vol.33 (10), p.2925-2929

1990

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Phenyl-substituted analogs of oxotremorine as muscarinic antagonists

Journal of medicinal chemistry, 1992-01, Vol.35 (2), p.285-294

1992

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Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester : potential antiglaucoma agents

Journal of medicinal chemistry, 1995-01, Vol.38 (2), p.289-304

1995

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Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1997-11, Vol.40 (23), p.3804-3819

1997

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Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase

Molecular pharmacology, 1991-06, Vol.39 (6), p.780-787

1991

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Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

European journal of pharmacology, 1998-04, Vol.346 (2-3), p.299-307

1998

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3-(2-Benzofuranyl)quinuclidin-2-ene Derivatives: Novel Muscarinic Antagonists

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3269-3277

1996

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Derivatives of cis-2-Amino-8-hydroxy-1-methyltetralin: Mixed 5-HT1A-Receptor Agonists and Dopamine D2-Receptor Antagonists

Journal of medicinal chemistry, 1995-01, Vol.38 (1), p.150-160

1995

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A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.497-510

1991

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Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1583-1586

1999

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beta.-Lactam analogs of oxotremorine. 3- and 4-Methyl-substituted 2-azetidinones

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.580-584

1990

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Derivatives of (R)- and (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: Synthesis and Interactions with 5-HT1A Receptors

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.4036-4043

1996

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Stereoselectivity of nicotinic receptors

Progress in brain research, 1989, Vol.79, p.95-100

1989

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Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain

Journal of medicinal chemistry, 1989-04, Vol.32 (4), p.779-783

1989

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Optimization of isochromanone based urotensin II receptor agonists

Design, Synthesis, and Structure−Activity Analysis of Isoform-Selective Retinoic Acid Receptor β Ligands

Design, parallel synthesis and SAR of novel urotensin II receptor agonists

Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

8-Hydroxy-2-(dipropylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist

3-Heteroaryl-Substituted Quinuclidin-3-ol and Quinuclidin-2-ene Derivatives as Muscarinic Antagonists. Synthesis and Structure-Activity Relationships

Isochromanone-based urotensin-II receptor agonists

Novel and potent small-molecule urotensin II receptor agonists

Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist

Synthesis and pharmacology of the enantiomers of cis-7-hydroxy-3-methyl-2-(dipropylamino)tetralin

Phenyl-substituted analogs of oxotremorine as muscarinic antagonists

Derivatives of 17-phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester : potential antiglaucoma agents

Antimuscarinic 3-(2-Furanyl)quinuclidin-2-ene Derivatives: Synthesis and Structure−Activity Relationships

Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase

Interactions of ligands with active and inactive conformations of the dopamine D2 receptor

3-(2-Benzofuranyl)quinuclidin-2-ene Derivatives: Novel Muscarinic Antagonists

Derivatives of cis-2-Amino-8-hydroxy-1-methyltetralin: Mixed 5-HT1A-Receptor Agonists and Dopamine D2-Receptor Antagonists

A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

Novel derivatives of 3-(dipropylamino)chroman. Interactions with 5-HT1A and D2A receptors

beta.-Lactam analogs of oxotremorine. 3- and 4-Methyl-substituted 2-azetidinones

Derivatives of (R)- and (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: Synthesis and Interactions with 5-HT1A Receptors

Stereoselectivity of nicotinic receptors

Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain

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