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Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Journal of medicinal chemistry, 1999-04, Vol.42 (7), p.1115-1122

1999

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Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Journal of medicinal chemistry, 2006-04, Vol.49 (7), p.2232-2240

2006

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Isochromanone-based urotensin-II receptor agonists

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (8), p.3057-3068

2005

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(R)- and (S)-8-acetyl-2-(dipropylamino)tetralin (LY-41) : two novel 5-HT1A receptor agonists

European journal of pharmacology, 1993-01, Vol.231 (1), p.69-76

1993

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Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4950-4953

2002

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Binding-site modeling of the muscarinic m1 receptor: a combination of homology-based and indirect approaches

Journal of medicinal chemistry, 1993-04, Vol.36 (8), p.967-976

1993

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Derivatives of (R)-1,11-Methyleneaporphine: Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1339-1349

2000

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Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase

Molecular pharmacology, 1991-06, Vol.39 (6), p.780-787

1991

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Differential serotoninergic and dopaminergic activities of the (R) - and the (S) -enantiomers of 2-(di-n-propylamino) tetralin

European journal of pharmacology, 1996-05, Vol.303 (3), p.151-162

1996

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Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4221-4229

1993

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A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.497-510

1991

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(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist

Journal of medicinal chemistry, 1990-06, Vol.33 (6), p.1541-1544

1990

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Stereoisomers of 3-(2,3-dihydrobenzofuran-2-yl)quinuclidine: Preparation and muscarinic receptor affinities

Chirality (New York, N.Y.), 1998, Vol.10 (9), p.813-820

1998

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Effects of ( R)-8-OH-DPAT and the enantiomers of UH-301 on motor activities in the rat: antagonism of ( R)-8-OH-DPAT-induced effects

European neuropsychopharmacology, 1992-06, Vol.2 (2), p.141-147

1992

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Derivatives of (R)- and (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: Synthesis and Interactions with 5-HT1A Receptors

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.4036-4043

1996

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Stereoselectivity of nicotinic receptors

Progress in brain research, 1989, Vol.79, p.95-100

1989

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Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain

Journal of medicinal chemistry, 1989-04, Vol.32 (4), p.779-783

1989

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Analogs of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology

Journal of medicinal chemistry, 1992-05, Vol.35 (9), p.1541-1550

1992

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Partial postsynaptic 5-HT1A agonist properties of the novel stereoselective 8-OH-DPAT analogue (+)cis-8-hydroxy-1-methyl-2-(di-n-propylamino)tetralin, (+)ALK-3

European journal of pharmacology, 1989-11, Vol.170 (3), p.269-274

1989

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Pharmacodynamic and Pharmacokinetic Studies in Rats of S-8-(2-Furyl)- and R-8-Phenyl-2-(di-n-Propylamino)Tetralin, Two Novel 5-HT1A Receptor Agonists In-vitro with Different Properties In-vivo

Journal of pharmacy and pharmacology, 1997-02, Vol.49 (2), p.169-177

1997

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Quinuclidin-2-ene - based muscarinic antagonists

Life sciences (1973), 1995, Vol.56 (11), p.831-836

1995

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5-Oxygenated N-Alkyl-and N,N-Dialkyl-2-amino-1-methyltetralins. Effects of Structure and Stereochemistry on Dopamine-D2-receptor Affinity

Journal of pharmacy and pharmacology, 1991-07, Vol.43 (7), p.481-485

1991

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(R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities

Chirality (New York, N.Y.), 1990, Vol.2 (2), p.90-95

1990

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(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist

Journal of medicinal chemistry, 1987-11, Vol.30 (11), p.2105-2109

1987

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Synthesis and pharmacology of the enantiomers of UH301: Opposing interactions with 5-HT1A receptors

Chirality (New York, N.Y.), 1996, Vol.8 (8), p.531-544

1996

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Characterization of the Binding Site of the Histamine H3 Receptor. 1. Various Approaches to the Synthesis of 2-(1H-Imidazol-4-yl)cyclopropylamine and Histaminergic Activity of (1R,2R)- and (1S,2S)-2-(1H-Imidazol-4-yl)- cyclopropylamine

Novel Potent and Efficacious Nonpeptidic Urotensin II Receptor Agonists

Isochromanone-based urotensin-II receptor agonists

(R)- and (S)-8-acetyl-2-(dipropylamino)tetralin (LY-41) : two novel 5-HT1A receptor agonists

Discovery of the First Nonpeptide Agonist of the GPR14/Urotensin-II Receptor: 3-(4-Chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954)

Binding-site modeling of the muscarinic m1 receptor: a combination of homology-based and indirect approaches

Derivatives of (R)-1,11-Methyleneaporphine: Synthesis, Structure, and Interactions with G-Protein Coupled Receptors

Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase

Differential serotoninergic and dopaminergic activities of the (R) - and the (S) -enantiomers of 2-(di-n-propylamino) tetralin

Derivatives of 2-(dipropylamino)tetralin: effect of the C8-substituent on the interaction with 5-HT1A receptors

A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin

(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: a putative 5-HT1A-receptor antagonist

Stereoisomers of 3-(2,3-dihydrobenzofuran-2-yl)quinuclidine: Preparation and muscarinic receptor affinities

Effects of ( R)-8-OH-DPAT and the enantiomers of UH-301 on motor activities in the rat: antagonism of ( R)-8-OH-DPAT-induced effects

Derivatives of (R)- and (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin: Synthesis and Interactions with 5-HT1A Receptors

Stereoselectivity of nicotinic receptors

Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain

Analogs of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology

Partial postsynaptic 5-HT1A agonist properties of the novel stereoselective 8-OH-DPAT analogue (+)cis-8-hydroxy-1-methyl-2-(di-n-propylamino)tetralin, (+)ALK-3

Pharmacodynamic and Pharmacokinetic Studies in Rats of S-8-(2-Furyl)- and R-8-Phenyl-2-(di-n-Propylamino)Tetralin, Two Novel 5-HT1A Receptor Agonists In-vitro with Different Properties In-vivo

Quinuclidin-2-ene - based muscarinic antagonists

5-Oxygenated N-Alkyl-and N,N-Dialkyl-2-amino-1-methyltetralins. Effects of Structure and Stereochemistry on Dopamine-D2-receptor Affinity

(R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities

(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist

Synthesis and pharmacology of the enantiomers of UH301: Opposing interactions with 5-HT1A receptors

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