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Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance

Current pharmacology reports, 2016, Vol.2 (3), p.161-169

Jamei, Masoud

2016

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Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy

Journal of pharmacokinetics and pharmacodynamics, 2020-08, Vol.47 (4), p.361-383

2020

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A Preterm Physiologically Based Pharmacokinetic Model. Part I: Physiological Parameters and Model Building

Clinical pharmacokinetics, 2020-04, Vol.59 (4), p.485-500

2020

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Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population

Clinical pharmacokinetics, 2020-04, Vol.59 (4), p.501-518

2020

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A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

Drug metabolism and pharmacokinetics, 2009-01, Vol.24 (1), p.53-75

2009

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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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An Application of a Physiologically Based Pharmacokinetic Approach to Predict Ceftazidime Pharmacokinetics in a Pregnant Population

Pharmaceutics, 2024-04, Vol.16 (4), p.474

2024

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Population-Based Mechanistic Prediction of Oral Drug Absorption

The AAPS journal, 2009-06, Vol.11 (2), p.225-237

2009

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Application of Physiologically Based Pharmacokinetic Model to Delineate the Impact of Aging and Renal Impairment on Ceftazidime Clearance

Antibiotics (Basel), 2024-09, Vol.13 (9), p.862

2024

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Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

Biopharmaceutics & drug disposition, 2015-05, Vol.36 (4), p.245-257

2015

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Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents

Pharmaceutics, 2021-07, Vol.13 (8), p.1169

2021

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Prediction of intestinal first-pass drug metabolism

Current drug metabolism, 2007-10, Vol.8 (7), p.676-684

2007

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Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen

Pharmaceutics, 2020-11, Vol.12 (11), p.1049

2020

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Application of a Physiologically Based Pharmacokinetic Approach to Predict Theophylline Pharmacokinetics Using Virtual Non-Pregnant, Pregnant, Fetal, Breast-Feeding, and Neonatal Populations

Frontiers in pediatrics, 2022-05, Vol.10, p.840710-840710

2022

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Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

Current drug metabolism, 2008-06, Vol.9 (5), p.384-393

2008

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Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

Drug metabolism and pharmacokinetics, 2016-06, Vol.31 (3), p.224-233

2016

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Developing Clinically Relevant Dissolution Specifications for Oral Drug Products-Industrial and Regulatory Perspectives

Pharmaceutics, 2019-12, Vol.12 (1), p.19

2019

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A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

Antibodies (Basel), 2024-09, Vol.13 (3), p.70

2024

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Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs

CPT: pharmacometrics and systems pharmacology, 2021-11, Vol.10 (11), p.1382-1395

2021

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Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

CPT: pharmacometrics and systems pharmacology, 2022-08, Vol.11 (8), p.1060-1084

2022

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Prediction of Concentration–Time Profile and its Inter-Individual Variability following the Dermal Drug Absorption

Journal of pharmaceutical sciences, 2012-07, Vol.101 (7), p.2584-2595

2012

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Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

Frontiers in pharmacology, 2018-03, Vol.9, p.247-247

2018

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Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Frontiers in immunology, 2015-01, Vol.5, p.670-670

2015

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Accelerating the Progress of Kinase Inhibitors in Oncology: The potential of PBPK modeling in answering key questions around these drugs

Applied clinical trials, 2024-05, Vol.33 (5), p.16

2024

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Accelerating the Progress of Kinase Inhibitors in Oncology

Applied clinical trials, 2024-05, Vol.33 (5), p.16-17

2024

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Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance

Prediction of maternal pharmacokinetics using physiologically based pharmacokinetic models: assessing the impact of the longitudinal changes in the activity of CYP1A2, CYP2D6 and CYP3A4 enzymes during pregnancy

A Preterm Physiologically Based Pharmacokinetic Model. Part I: Physiological Parameters and Model Building

Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

PBPK models for the prediction of in vivo performance of oral dosage forms

An Application of a Physiologically Based Pharmacokinetic Approach to Predict Ceftazidime Pharmacokinetics in a Pregnant Population

Population-Based Mechanistic Prediction of Oral Drug Absorption

Application of Physiologically Based Pharmacokinetic Model to Delineate the Impact of Aging and Renal Impairment on Ceftazidime Clearance

Does age affect gastric emptying time? A model-based meta-analysis of data from premature neonates through to adults

Mechanistic PBPK Modelling to Predict the Advantage of the Salt Form of a Drug When Dosed with Acid Reducing Agents

Prediction of intestinal first-pass drug metabolism

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen

Application of a Physiologically Based Pharmacokinetic Approach to Predict Theophylline Pharmacokinetics Using Virtual Non-Pregnant, Pregnant, Fetal, Breast-Feeding, and Neonatal Populations

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

Developing Clinically Relevant Dissolution Specifications for Oral Drug Products-Industrial and Regulatory Perspectives

A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs

Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

Prediction of Concentration–Time Profile and its Inter-Individual Variability following the Dermal Drug Absorption

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Accelerating the Progress of Kinase Inhibitors in Oncology: The potential of PBPK modeling in answering key questions around these drugs

Accelerating the Progress of Kinase Inhibitors in Oncology

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