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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Nature, 2009-01, Vol.457 (7229), p.585-588

2009

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MD-2 is required for disulfide HMGB1-dependent TLR4 signaling

The Journal of experimental medicine, 2015-01, Vol.212 (1), p.5-14

2015

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Morphine activates neuroinflammation in a manner parallel to endotoxin

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (16), p.6325-6330

2012

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Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex

Nature communications, 2017-12, Vol.8 (1), p.2247-2247, Article 2247

2017

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Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14 + Monocytes

The Journal of immunology (1950), 2017-03, Vol.198 (6), p.2286-2301

2017

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The molecular basis of the host response to lipopolysaccharide

Nature reviews. Microbiology, 2010-01, Vol.8 (1), p.8-14

2010

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Structures of the Toll-like Receptor Family and Its Ligand Complexes

Immunity (Cambridge, Mass.), 2008-08, Vol.29 (2), p.182-191

2008

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Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β

PloS one, 2017-05, Vol.12 (5), p.e0176793

2017

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Cisplatin Toxicity Is Mediated by Direct Binding to Toll-Like Receptor 4 through a Mechanism That Is Distinct from Metal Allergens

Molecular pharmacology, 2023-03, Vol.103 (3), p.158-165

2023

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Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage

The Journal of neuroscience, 2010-06, Vol.30 (24), p.8285-8295

2010

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Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran

Cell, 2007-09, Vol.130 (5), p.906-917

2007

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Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (19), p.7421-7426

2012

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Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats

American journal of physiology. Renal physiology, 2019-08, Vol.317 (2), p.F361-F374

2019

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MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

Nature communications, 2020-05, Vol.11 (1), p.2148-2148, Article 2148

2020

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Immunoinformatics approach to understand molecular interaction between multi-epitopic regions of SARS-CoV-2 spike-protein with TLR4/MD-2 complex

Infection, genetics and evolution, 2020-11, Vol.85, p.104587-104587, Article 104587

2020

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Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

The Journal of biological chemistry, 2012-11, Vol.287 (48), p.40611-40617

2012

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Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery

The Journal of biological chemistry, 2020-12, Vol.295 (51), p.17842-17851

2020

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Oxidized Phospholipid Inhibition of Toll-like Receptor (TLR) Signaling Is Restricted to TLR2 and TLR4: ROLES FOR CD14, LPS-BINDING PROTEIN, AND MD2 AS TARGETS FOR SPECIFICITY OF INHIBITION

The Journal of biological chemistry, 2008-09, Vol.283 (36), p.24748-24759

2008

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Interaction between polysaccharides and toll-like receptor 4: Primary structural role, immune balance perspective, and 3D interaction model hypothesis

Food chemistry, 2022-04, Vol.374, p.131586-131586, Article 131586

2022

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Sulfatides are endogenous ligands for the TLR4-MD-2 complex

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (30)

2021

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Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14

BMB Reports, 2017, 50(2), , pp.55-57

2017

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The TLR4 antagonist Eritoran protects mice from lethal influenza infection

Nature (London), 2013-05, Vol.497 (7450), p.498-502

2013

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In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

International journal of molecular sciences, 2024-05, Vol.25 (10), p.5451

Kircheis, Ralf

2024

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Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

EMBO reports, 2012-12, Vol.13 (12), p.1109-1115

2012

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Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization

Science signaling, 2017-10, Vol.10 (503)

2017

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

MD-2 is required for disulfide HMGB1-dependent TLR4 signaling

Morphine activates neuroinflammation in a manner parallel to endotoxin

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4-MD2 complex

Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14 + Monocytes

The molecular basis of the host response to lipopolysaccharide

Structures of the Toll-like Receptor Family and Its Ligand Complexes

Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β

Cisplatin Toxicity Is Mediated by Direct Binding to Toll-Like Receptor 4 through a Mechanism That Is Distinct from Metal Allergens

Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage

Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats

MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

Immunoinformatics approach to understand molecular interaction between multi-epitopic regions of SARS-CoV-2 spike-protein with TLR4/MD-2 complex

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery

Oxidized Phospholipid Inhibition of Toll-like Receptor (TLR) Signaling Is Restricted to TLR2 and TLR4: ROLES FOR CD14, LPS-BINDING PROTEIN, AND MD2 AS TARGETS FOR SPECIFICITY OF INHIBITION

Interaction between polysaccharides and toll-like receptor 4: Primary structural role, immune balance perspective, and 3D interaction model hypothesis

Sulfatides are endogenous ligands for the TLR4-MD-2 complex

Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization

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