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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

PloS one, 2019-02, Vol.14 (2), p.e0211568-e0211568

2019

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

PloS one, 2017-05, Vol.12 (5), p.e0176182-e0176182

2017

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Using a Function-First “Scout Fragment”-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes

Journal of the American Chemical Society, 2024-01, Vol.146 (1), p.62-67

2024

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Bioorganic & medicinal chemistry letters, 2020-07, Vol.30 (13), p.127197-127197, Article 127197

2020

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Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation

Journal of chemical information and modeling, 2023-05, Vol.63 (9), p.2828-2841

2023

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Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127367-127367, Article 127367

2020

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Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Bioorganic & medicinal chemistry letters, 2021-09, Vol.47, p.128168-128168, Article 128168

2021

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2069-2073

2017

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Bioorganic & medicinal chemistry letters, 2017-05, Vol.27 (9), p.2063-2068

2017

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Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor

SLAS discovery, 2017-10, Vol.22 (9), p.1131-1141

2017

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Enzymatic preparation of high-specific-activity β- d-[6,6′- 3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase

Analytical biochemistry, 2010-11, Vol.406 (2), p.97-104

2010

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Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (20), p.3405-3408

2003

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A new class of glycogen phosphorylase inhibitors

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4125-4128

2003

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Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4385-4388

2003

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Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Journal of the American Chemical Society, 1996-03, Vol.118 (10), p.2359-2365

1996

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Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 1

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.107-111

2001

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Modeling aided design of potent glycogen phosphorylase inhibitors

Journal of molecular graphics & modelling, 2005-04, Vol.23 (5), p.457-464

2005

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Sediment discharge prediction in meandering compound channels

Journal of hydraulic research, 2006-01, Vol.44 (5), p.603-613

2006

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Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors

Tetrahedron letters, 2000-10, Vol.41 (41), p.7831-7835

2000

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Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs

Tetrahedron letters, 2000-10, Vol.41 (41), p.7837-7841

2000

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N-Substituted (β- d-galactopyranosylmethyl)amines as reversible inhibitors of β- d-galactosidase

Carbohydrate research, 1993-12, Vol.250 (1), p.93-100

1993

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Suicide-substrate inactivation of β-galactosidase by diazomethyl β- d-galactopyranosyl ketone

Carbohydrate research, 1993-12, Vol.250 (1), p.101-112

1993

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Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2

Bioorganic & medicinal chemistry letters, 2001-01, Vol.11 (2), p.113-117

2001

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Development of a Scintillation Proximity Assay for Histone Deacetylase Using a Biotinylated Peptide Derived from Histone-H4

Analytical biochemistry, 1999-02, Vol.267 (2), p.390-396

1999

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N-Substituted (β- d-galactopyranosylmethyl)amines, and C-β- d-galactopyranosylformamides, and related compounds

Carbohydrate research, 1990-04, Vol.200, p.111-126

1990

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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

Using a Function-First “Scout Fragment”-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes

Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation

Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir

Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus

Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus

Label-Free, LC-MS-Based Assays to Quantitate Small-Molecule Antagonist Binding to the Mammalian BLT1 Receptor

Enzymatic preparation of high-specific-activity β- d-[6,6′- 3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors

A new class of glycogen phosphorylase inhibitors

Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a

Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 1

Modeling aided design of potent glycogen phosphorylase inhibitors

Sediment discharge prediction in meandering compound channels

Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors

Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs

N-Substituted (β- d-galactopyranosylmethyl)amines as reversible inhibitors of β- d-galactosidase

Suicide-substrate inactivation of β-galactosidase by diazomethyl β- d-galactopyranosyl ketone

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2

Development of a Scintillation Proximity Assay for Histone Deacetylase Using a Biotinylated Peptide Derived from Histone-H4

N-Substituted (β- d-galactopyranosylmethyl)amines, and C-β- d-galactopyranosylformamides, and related compounds

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