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Exuberant fibroblast activity compromises lung function via ADAMTS4

Nature (London), 2020-11, Vol.587 (7834), p.466-471

2020

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Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Biochimica et biophysica acta. General subjects, 2021-03, Vol.1865 (3), p.129833, Article 129833

2021

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Raloxifene retards cartilage degradation and improves subchondral bone micro-architecture in ovariectomized rats with patella baja-induced - patellofemoral joint osteoarthritis

Osteoarthritis and cartilage, 2020-03, Vol.28 (3), p.344-355

2020

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A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5933-5939

2017

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Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

Scientific reports, 2017-09, Vol.7 (1), p.12351-14, Article 12351

2017

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Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages

Cellular physiology and biochemistry, 2018-05, Vol.46 (4), p.1693-1703

2018

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MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes

Cellular physiology and biochemistry, 2017-01, Vol.44 (1), p.38-52

2017

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LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes

The FASEB journal, 2017-07, Vol.31 (7), p.3116-3125

2017

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miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4

Archives of virology, 2024-08, Vol.169 (8), p.164, Article 164

2024

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Measurement of Protease Activities Using Fluorogenic Substrates

Methods in molecular biology (Clifton, N.J.), 2018-01, Vol.1731, p.107

2018

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Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro

Bioscience reports, 2019-05, Vol.39 (5)

2019

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Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries

Scientific reports, 2022-06, Vol.12 (1), p.9898-9898, Article 9898

2022

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Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

The Journal of clinical investigation, 2016-05, Vol.126 (5), p.1649-1663

2016

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Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytes

PloS one, 2020-12, Vol.15 (12), p.e0243359-e0243359

2020

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Chrysin downregulates the expression of ADAMTS-4 in foam cells

Molecular biology reports, 2024-12, Vol.51 (1), p.968, Article 968

2024

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Establishment of a Rabbit Model of Adjacent Intervertebral Disk Degeneration After Lumbar Fusion and Fixation and Evaluation of Autophagy Factor Expression in Nucleus Pulposus Cells

Orthopedics (Thorofare, N.J.), 2024-07, Vol.47 (4), p.e167

2024

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Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts

Laboratory investigation, 2022-01, Vol.102 (1), p.102-111

2022

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β-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis

Histology and histopathology, 2021-07, Vol.36 (7), p.785-794

2021

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Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture

The veterinary journal (1997), 2021-06, Vol.272, p.105657-105657, Article 105657

2021

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Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes

Cellular physiology and biochemistry, 2017-01, Vol.43 (3), p.937-944

2017

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Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan‐Enriched Extracellular Matrix Adhesive for Monocytes

Journal of cellular biochemistry, 2017-08, Vol.118 (8), p.2118-2130

2017

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Juglanin inhibits IL-1β-induced inflammation in human chondrocytes

Artificial cells, nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.3614-3620

2019

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Lycorine Suppresses Endplate-Chondrocyte Degeneration and Prevents Intervertebral Disc Degeneration by Inhibiting NF-κB Signalling Pathway

Cellular physiology and biochemistry, 2018-01, Vol.45 (3), p.1252-1269

2018

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Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms

Arthritis & rheumatology (Hoboken, N.J.), 2017-08, Vol.69 (8), p.1601-1611

2017

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Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4

Bioorganic chemistry, 2018-02, Vol.76, p.13-22

2018

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Exuberant fibroblast activity compromises lung function via ADAMTS4

Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Raloxifene retards cartilage degradation and improves subchondral bone micro-architecture in ovariectomized rats with patella baja-induced - patellofemoral joint osteoarthritis

A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose

Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice

Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages

MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes

LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes

miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4

Measurement of Protease Activities Using Fluorogenic Substrates

Resveratrol attenuates inflammation environment-induced nucleus pulposus cell senescence in vitro

Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

Comparative intra-articular gene transfer of seven adeno-associated virus serotypes reveals that AAV2 mediates the most efficient transduction to mouse arthritic chondrocytes

Chrysin downregulates the expression of ADAMTS-4 in foam cells

Establishment of a Rabbit Model of Adjacent Intervertebral Disk Degeneration After Lumbar Fusion and Fixation and Evaluation of Autophagy Factor Expression in Nucleus Pulposus Cells

Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts

β-Ecdysone attenuates cartilage damage in a mouse model of collagenase-induced osteoarthritis via mediating FOXO1/ADAMTS-4/5 signaling axis

Characterisation of key proteoglycans in the cranial cruciate ligaments (CCLs) from two dog breeds with different predispositions to CCL disease and rupture

Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes

Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan‐Enriched Extracellular Matrix Adhesive for Monocytes

Juglanin inhibits IL-1β-induced inflammation in human chondrocytes

Lycorine Suppresses Endplate-Chondrocyte Degeneration and Prevents Intervertebral Disc Degeneration by Inhibiting NF-κB Signalling Pathway

Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms

Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4

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