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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Nature communications, 2021-05, Vol.12 (1), p.2623-2623, Article 2623

2021

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Drug Intelligence Science (DIS®): Pioneering a high-resolution translational platform to enhance the probability of success for drug discovery and development

Drug discovery today, 2023-11, Vol.28 (11), p.103795-103795, Article 103795

Schweizer, Liang

2023

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Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Molecular cancer therapeutics, 2015-10, Vol.14 (10), p.2167-2174

2015

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Targeting epigenetic regulators for cancer therapy

Annals of the New York Academy of Sciences, 2014-02, Vol.1309 (1), p.30-36

2014

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Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled

Molecular and Cellular Biology, 2004-03, Vol.24 (5), p.2000-2011

2004

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Global or local: The future of biotech

Drug discovery today, 2023-05, Vol.28 (5), p.103528-103528, Article 103528

2023

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Safety, tolerability, pharmacokinetics, and immunogenicity of an anti-SARS-CoV-2 monoclonal antibody HFB30132A after single dose intravenous administration in healthy Chinese subjects: a phase 1, randomized, double-blind, placebo-controlled study

Frontiers in pharmacology, 2023-05, Vol.14, p.1117293-1117293

2023

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Guiding principles of value creation through collaborative innovation in pharmaceutical research

Drug discovery today, 2018-02, Vol.23 (2), p.213-218

2018

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Requirement for a Nuclear Function of β-Catenin in Wnt Signaling

Molecular and Cellular Biology, 2003-12, Vol.23 (23), p.8462-8470

2003

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SDRS—an algorithm for analyzing large-scale dose–response data

Bioinformatics, 2011-10, Vol.27 (20), p.2921-2923

2011

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Requirement for Pangolin/dTCF in Drosophila Wingless Signaling

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.5846-5851

2003

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Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells

Molecular biology of the cell, 1998-12, Vol.9 (12), p.3505-3519

1998

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Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Development (Cambridge), 2004-10, Vol.131 (20), p.5103-5115

2004

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Abstract 6532: HFB9-2: A novel Gal-9 neutralizing antibody to reverse immune suppression in the tumor microenvironment

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6532-6532

2020

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High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics

Science advances, 2021-06, Vol.7 (24)

2021

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Abstract PO-048: Combined single-T cell clonotyping and phenotyping defines a predictive response signature that identifies patients more likely to respond to therapy

Cancer research (Chicago, Ill.), 2020-11, Vol.80 (21_Supplement), p.PO-048-PO-048

2020

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Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Bioorganic & medicinal chemistry letters, 2024-01, Vol.98, p.129589-129589, Article 129589

2024

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Abstract 1843: Dicovery and characterization of a novel anti-human CXCR5 antibody for the treatment of B cell lymphomas

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1843-1843

2021

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Abstract 2282: Discovery and characterization of novel TNFR2 antibodies to modulate T cell activities in immunosuppressive environment

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2282-2282

2020

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Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1883-1883

2021

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Abstract 1884: HFB9-2, a novel Galectin 9 neutralizing antibody for the treatment of AML and other cancers

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1884-1884

2021

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Abstract 1882: Clinical approach and biomarker strategy for HFB301001, a novel OX40 agonistic antibody

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1882-1882

2021

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Abstract 2285: HFB10-1E1, a novel OX-40 agonistic antibody with a unique pharmacological profile and biomarker strategy

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2285-2285

2020

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Abstract 4248: HFB200603, a novel anti-BTLA monoclonal antibody that provides therapeutic potential for immune escape and synergizes with anti-PD-1 treatment

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.4248-4248

2022

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Abstract 618: Discovery of predictive biomarkers of response to T cell-targeting biologics using ex vivo single-cell profiling coupled with TCR clonotype characterization

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.618-618

2022

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A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Drug Intelligence Science (DIS®): Pioneering a high-resolution translational platform to enhance the probability of success for drug discovery and development

Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression

Targeting epigenetic regulators for cancer therapy

Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled

Global or local: The future of biotech

Safety, tolerability, pharmacokinetics, and immunogenicity of an anti-SARS-CoV-2 monoclonal antibody HFB30132A after single dose intravenous administration in healthy Chinese subjects: a phase 1, randomized, double-blind, placebo-controlled study

Guiding principles of value creation through collaborative innovation in pharmaceutical research

Requirement for a Nuclear Function of β-Catenin in Wnt Signaling

SDRS—an algorithm for analyzing large-scale dose–response data

Requirement for Pangolin/dTCF in Drosophila Wingless Signaling

Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Abstract 6532: HFB9-2: A novel Gal-9 neutralizing antibody to reverse immune suppression in the tumor microenvironment

High-throughput functional screening for next-generation cancer immunotherapy using droplet-based microfluidics

Abstract PO-048: Combined single-T cell clonotyping and phenotyping defines a predictive response signature that identifies patients more likely to respond to therapy

Exploration of macrocyclic peptide binders to the extracellular CRD domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1)

Abstract 1843: Dicovery and characterization of a novel anti-human CXCR5 antibody for the treatment of B cell lymphomas

Abstract 2282: Discovery and characterization of novel TNFR2 antibodies to modulate T cell activities in immunosuppressive environment

Abstract 1883: Mechanism of action and biomarker strategy for HFB200301, an anti-TNFR2 agonist antibody for the treatment of cancer

Abstract 1884: HFB9-2, a novel Galectin 9 neutralizing antibody for the treatment of AML and other cancers

Abstract 1882: Clinical approach and biomarker strategy for HFB301001, a novel OX40 agonistic antibody

Abstract 2285: HFB10-1E1, a novel OX-40 agonistic antibody with a unique pharmacological profile and biomarker strategy

Abstract 4248: HFB200603, a novel anti-BTLA monoclonal antibody that provides therapeutic potential for immune escape and synergizes with anti-PD-1 treatment

Abstract 618: Discovery of predictive biomarkers of response to T cell-targeting biologics using ex vivo single-cell profiling coupled with TCR clonotype characterization

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