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Orphan G-protein-coupled receptors and natural ligand discovery

Trends in Pharmacological Sciences, 2001-03, Vol.22 (3), p.132-140

2001

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Peptidomimetic Regulation of Growth Hormone Secretion

Endocrine reviews, 1997-10, Vol.18 (5), p.621-645

1997

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2002 Alfred Burger Award Address in Medicinal Chemistry. Natural Products and Design: Interrelated Approaches in Drug Discovery

Journal of medicinal chemistry, 2002-12, Vol.45 (26), p.5609-5616

Patchett, Arthur A

2002

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Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues

Molecular endocrinology (Baltimore, Md.), 1998-01, Vol.12 (1), p.137-145

1998

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Peptidomimetic Growth Hormone Secretagogues. Design Considerations and Therapeutic Potential

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3103-3127

1998

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Spiro[1H-indene-1,4‘-piperidine] Derivatives As Potent and Selective Non-Peptide Human Somatostatin Receptor Subtype 2 (sst2) Agonists

Journal of medicinal chemistry, 1998-06, Vol.41 (13), p.2175-2179

1998

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Identification of a new G-protein-linked receptor for growth hormone secretagogues

Molecular endocrinology (Baltimore, Md.), 1996-01, Vol.10 (1), p.57-61

1996

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Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1130-1133

2006

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Ligand Activation Domain of Human Orphan Growth Hormone (GH) Secretagogue Receptor (GHS-R) Conserved from Pufferfish to Humans

Molecular endocrinology (Baltimore, Md.), 2000-01, Vol.14 (1), p.160-169

2000

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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3501-3505

2005

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Excursions in drug discovery

Journal of medicinal chemistry, 1993-07, Vol.36 (15), p.2051-2058

Patchett, Arthur A

1993

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A high proportion of fat relative to muscle mass is associated with poor bone strength and balance in pre-pubertal boys and girls: Implications for fracture risk

Bone (New York, N.Y.), 2009-07, Vol.45, p.S57-S57

2009

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Physical fitness is associated with greater bone strength in prepubertal children, irrespective of their body weight

Bone (New York, N.Y.), 2009-05, Vol.44, p.S58-S58

2009

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1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3430-3433

2005

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In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1992-07, Vol.262 (1), p.133

1992

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Synthesis and Structure-Activity Relationships of Peptidyl .alpha.-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3492-3502

1994

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2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists

Bioorganic & medicinal chemistry letters, 2005-04, Vol.15 (8), p.1993-1996

2005

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Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (14), p.1955-1957

2001

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Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1261-1266

1999

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Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles

Journal of endocrinology, 1997-02, Vol.152 (2), p.183-192

1997

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In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1992-07, Vol.262 (1), p.139

1992

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1-[2(R)-(2-Amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)-carboxylic Acid Ethyl Ester (L-163,540): A Potent, Orally Bioavailable, and Short-Duration Growth Hormone Secretagogue

Journal of medicinal chemistry, 1998-07, Vol.41 (14), p.2439-2441

1998

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Orphan G-protein-coupled receptors and natural ligand discovery

Peptidomimetic Regulation of Growth Hormone Secretion

Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist

2002 Alfred Burger Award Address in Medicinal Chemistry. Natural Products and Design: Interrelated Approaches in Drug Discovery

Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues

Peptidomimetic Growth Hormone Secretagogues. Design Considerations and Therapeutic Potential

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future

Spiro[1H-indene-1,4‘-piperidine] Derivatives As Potent and Selective Non-Peptide Human Somatostatin Receptor Subtype 2 (sst2) Agonists

Identification of a new G-protein-linked receptor for growth hormone secretagogues

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Ligand Activation Domain of Human Orphan Growth Hormone (GH) Secretagogue Receptor (GHS-R) Conserved from Pufferfish to Humans

Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Discovery of (2 S)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Excursions in drug discovery

A high proportion of fat relative to muscle mass is associated with poor bone strength and balance in pre-pubertal boys and girls: Implications for fracture risk

Physical fitness is associated with greater bone strength in prepubertal children, irrespective of their body weight

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists

In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist

Synthesis and Structure-Activity Relationships of Peptidyl .alpha.-Keto Heterocycles as Novel Inhibitors of Prolyl Endopeptidase

2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists

Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics

Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues

Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles

In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist

1-[2(R)-(2-Amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]-3- benzylpiperidine-3(S)-carboxylic Acid Ethyl Ester (L-163,540): A Potent, Orally Bioavailable, and Short-Duration Growth Hormone Secretagogue

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