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Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

Nature reviews. Drug discovery, 2022-05, Vol.21 (5), p.359-378

2022

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A roadmap for metagenomic enzyme discovery

Natural product reports, 2021-11, Vol.38 (11), p.1994-223

2021

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Site-specific bioorthogonal protein labelling by tetrazine ligation using endogenous β-amino acid dienophiles

Nature chemistry, 2023-10, Vol.15 (10), p.1422-1430

2023

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Biosynthesis of polyketides by trans-AT polyketide synthases

Natural product reports, 2016-02, Vol.33 (2), p.231-316

2016

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A Polyketide Synthase-Peptide Synthetase Gene Cluster from an Uncultured Bacterial Symbiont of Paederus Beetles

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (22), p.14002-14007

Piel, Jörn

2002

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In Vivo Production of Diverse β‐Amino Acid‐Containing Proteins

Angewandte Chemie International Edition, 2022-07, Vol.61 (29), p.e202202695-n/a

International ed. in English, 2022

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Genomic insights into the marine sponge microbiome

Nature reviews. Microbiology, 2012-09, Vol.10 (9), p.641-654

2012

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The hidden enzymology of bacterial natural product biosynthesis

Nature reviews. Chemistry, 2019-07, Vol.3 (7), p.404-425

2019

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Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

Genome biology and evolution, 2020-11, Vol.12 (11), p.1975-1987

2020

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Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

Annual review of microbiology, 2011-01, Vol.65 (1), p.431-453

Piel, Jörn

2011

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Automated structure prediction of trans-acyltransferase polyketide synthase products

Nature chemical biology, 2019-08, Vol.15 (8), p.813-821

2019

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Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

Organic letters, 2018-09, Vol.20 (17), p.5238-5241

2018

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Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

Science (American Association for the Advancement of Science), 2012-10, Vol.338 (6105), p.387-390

2012

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Ribosomally derived lipopeptides containing distinct fatty acyl moieties

Proceedings of the National Academy of Sciences - PNAS, 2022-01, Vol.119 (3)

2022

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Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Nature chemical biology, 2017-08, Vol.13 (8), p.833-835

2017

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Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6377), p.779-782

2018

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Metabolites from symbiotic bacteria

Natural product reports, 2004-08, Vol.21 (4), p.519-538

Piel, Jorn

2004

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Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining

Angewandte Chemie International Edition, 2020-07, Vol.59 (29), p.11763-11768

International ed. in English, 2020

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Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria

BMC genomics, 2014-11, Vol.15 (1), p.977-977, Article 977

2014

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Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (3), p.E347-E356

2017

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Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

Nature chemistry, 2017-04, Vol.9 (4), p.387

2017

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Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

Current opinion in chemical biology, 2016-04, Vol.31, p.8-14

2016

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Paradigm Shift for Radical S‑Adenosyl‑l‑methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

Journal of the American Chemical Society, 2018-07, Vol.140 (28), p.8634-8638

2018

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Genome mining- and synthetic biology-enabled production of hypermodified peptides

Nature chemistry, 2019-10, Vol.11 (10), p.931-939

2019

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Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains

Chemical science (Cambridge), 2013-01, Vol.4 (3), p.1041-1045

2013

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Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

A roadmap for metagenomic enzyme discovery

Site-specific bioorthogonal protein labelling by tetrazine ligation using endogenous β-amino acid dienophiles

Biosynthesis of polyketides by trans-AT polyketide synthases

A Polyketide Synthase-Peptide Synthetase Gene Cluster from an Uncultured Bacterial Symbiont of Paederus Beetles

In Vivo Production of Diverse β‐Amino Acid‐Containing Proteins

Genomic insights into the marine sponge microbiome

The hidden enzymology of bacterial natural product biosynthesis

Comparative Genomics Underlines Multiple Roles of Profftella, an Obligate Symbiont of Psyllids: Providing Toxins, Vitamins, and Carotenoids

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

Automated structure prediction of trans-acyltransferase polyketide synthase products

Aranazoles: Extensively Chlorinated Nonribosomal Peptide–Polyketide Hybrids from the Cyanobacterium Fischerella sp. PCC 9339

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

Ribosomally derived lipopeptides containing distinct fatty acyl moieties

Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products

Natural noncanonical protein splicing yields products with diverse β-amino acid residues

Metabolites from symbiotic bacteria

Landornamides: Antiviral Ornithine‐Containing Ribosomal Peptides Discovered through Genome Mining

Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

Paradigm Shift for Radical S‑Adenosyl‑l‑methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

Genome mining- and synthetic biology-enabled production of hypermodified peptides

Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains

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