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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Nature communications, 2022-01, Vol.13 (1), p.486-486, Article 486

2022

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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Molecular cell, 2019-12, Vol.76 (6), p.872-884.e5

2019

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Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice

PloS one, 2012-09, Vol.7 (9), p.e45243-e45243

2012

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Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Molecular cell, 2016-12, Vol.64 (5), p.875-887

2016

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Targeting the Raf kinases in human cancer: the Raf dimer dilemma

British journal of cancer, 2018-01, Vol.118 (1), p.3-8

2018

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A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

Biochimica et biophysica acta. General subjects, 2020-06, Vol.1864 (6), p.129556-129556, Article 129556

2020

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Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Molecular pharmacology, 2014-03, Vol.85 (3), p.408-419

2014

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Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1743-1754

2021

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Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Journal of natural products (Washington, D.C.), 2022-06, Vol.85 (6), p.1603-1616

2022

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Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

Basic research in cardiology, 2015-05, Vol.110 (3), p.31-31, Article 31

2015

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Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

Molecular pharmacology, 2015-09, Vol.88 (3), p.512-523

2015

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Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction

Journal of natural products (Washington, D.C.), 2020-04, Vol.83 (4), p.1288-1294

2020

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Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3431-3435

2010

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Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor

Investigational new drugs, 2012-08, Vol.30 (4), p.1379-1388

2012

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Development of water soluble derivatives of cis-3, 4′, 5-trimethoxy-3′-aminostilbene for optimization and use in cancer therapy

Investigational new drugs, 2009-02, Vol.27 (1), p.41-52

2009

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Abstract 16201: Combined Treatment of the PI3k/mTOR Inhibitor BEZ235 With Doxorubicin Does Not Increase Cardiotoxicity While Improving Efficacy in Breast Cancer Cells

Circulation (New York, N.Y.), 2014-11, Vol.130 (suppl_2)

2014

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Abstract 16163: Hydrogen Sulfide Reduces Inflammasome Formation in Mice With Ischemic HFrEF

Circulation (New York, N.Y.), 2015-11, Vol.132 (Suppl_3 Suppl 3), p.A16163-A16163

2015

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Abstract 9812: Dietary Supplementation of Nitrite Reduces Chronic Cardiotoxicity of Doxorubicin: Role of Activation of Protein Kinase G and Down-Regulation of Endothelial Nitric Oxide Synthase in Heart

Circulation (New York, N.Y.), 2011-11, Vol.124 (suppl_21)

2011

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Development of water soluble derivatives of cis-3, 4 double prime , 5-trimethoxy-3 double prime -aminostilbene for optimization and use in cancer therapy

Investigational new drugs, 2009-02, Vol.27 (1), p.41-52

2009

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ChemInform Abstract: Versatile Synthesis of New Cytotoxic Agents Structurally Related to Hemiasterlins

ChemInform, 2010-11, Vol.41 (45), p.no-no

2010

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Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals

mBio, 2014-08, Vol.5 (5), p.e01476-e01414

2014

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A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Cell, 2015-06, Vol.161 (7), p.1619-1632

2015

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Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

Cell metabolism, 2016-10, Vol.24 (4), p.555-565

2016

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Charge Separation versus Recombination in Dye-Sensitized Nanocrystalline Solar Cells: the Minimization of Kinetic Redundancy

Journal of the American Chemical Society, 2005-03, Vol.127 (10), p.3456-3462

2005

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Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Journal of medicinal chemistry, 2011-04, Vol.54 (7), p.2320-2330

2011

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Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Targeting the Raf kinases in human cancer: the Raf dimer dilemma

A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines

Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells

Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction

Tolypocladamides A–G: Cytotoxic Peptaibols from Tolypocladium inflatum

Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling

Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity

Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction

Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins

Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor

Development of water soluble derivatives of cis-3, 4′, 5-trimethoxy-3′-aminostilbene for optimization and use in cancer therapy

Abstract 16201: Combined Treatment of the PI3k/mTOR Inhibitor BEZ235 With Doxorubicin Does Not Increase Cardiotoxicity While Improving Efficacy in Breast Cancer Cells

Abstract 16163: Hydrogen Sulfide Reduces Inflammasome Formation in Mice With Ischemic HFrEF

Abstract 9812: Dietary Supplementation of Nitrite Reduces Chronic Cardiotoxicity of Doxorubicin: Role of Activation of Protein Kinase G and Down-Regulation of Endothelial Nitric Oxide Synthase in Heart

Development of water soluble derivatives of cis-3, 4 double prime , 5-trimethoxy-3 double prime -aminostilbene for optimization and use in cancer therapy

ChemInform Abstract: Versatile Synthesis of New Cytotoxic Agents Structurally Related to Hemiasterlins

Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals

A Single Kinase Generates the Majority of the Secreted Phosphoproteome

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

Charge Separation versus Recombination in Dye-Sensitized Nanocrystalline Solar Cells: the Minimization of Kinetic Redundancy

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

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