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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

EMBO molecular medicine, 2015-04, Vol.7 (4), p.394-410

2015

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Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

Scientific reports, 2024-05, Vol.14 (1), p.11105-11105, Article 11105

2024

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Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies

Journal of neuroscience research, 2002-11, Vol.70 (4), p.529-545

2002

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Ion channels as drug targets in central nervous system disorders

Current medicinal chemistry, 2013-04, Vol.20 (10), p.1241-1285

2013

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Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

British journal of pharmacology, 2021-07, Vol.178 (13), p.2617-2631

2021

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COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

The Journal of pharmacology and experimental therapeutics, 2021-05, Vol.377 (2), p.265-272

2021

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Neural KCNQ (Kv7) channels

British journal of pharmacology, 2009-04, Vol.156 (8), p.1185-1195

2009

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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Proceedings of the National Academy of Sciences - PNAS, 2023-01, Vol.120 (2), p.e2211977120-e2211977120

2023

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5963), p.348-351

2010

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Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Canadian journal of physiology and pharmacology, 2023-01, Vol.101 (1), p.41-51

2023

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K Ca channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Scientific reports, 2021-09, Vol.11 (1), p.18330

2021

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Towards a Structural View of Drug Binding to hERG K+ Channels

Trends in pharmacological sciences (Regular ed.), 2017-10, Vol.38 (10), p.899-907

2017

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Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade

Circulation (New York, N.Y.), 2015-12, Vol.132 (23), p.2203-2211

2015

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Differential potassium channel inhibitory activities of a novel thermostable degradation peptide BmKcug1a-P1 from scorpion medicinal material and its N-terminal truncated/restored peptides

Scientific reports, 2024-07, Vol.14 (1), p.16092-11, Article 16092

2024

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Multiple hERG channel blocking pathways: implications for macromolecules

Trends in pharmacological sciences (Regular ed.), 2024-08, Vol.45 (8), p.671-677

Zünkler, Bernd J.

2024

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Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin

The Journal of biological chemistry, 2016-03, Vol.291 (13), p.7097-7106

2016

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N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel Kv1.3

The FEBS journal, 2015-06, Vol.282 (12), p.2247-2259

2015

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Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

The Journal of general physiology, 2019-02, Vol.151 (2), p.214-230

2019

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Ions and blockers in potassium channels: insights from free energy simulations

Biochimica et biophysica acta, 2005-02, Vol.1747 (1), p.109-120

2005

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Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K + channel pathway

Canadian journal of physiology and pharmacology, 2022-04, Vol.100 (4), p.306-313

2022

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Crystal Structure of the Human K2P TRAAK, a Lipid-and Mechano-Sensitive K⁺ Ion Channel

Science (American Association for the Advancement of Science), 2012-01, Vol.335 (6067), p.436-441

2012

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Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

The New England journal of medicine, 2010-10, Vol.363 (15), p.1397-1409

2010

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Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

Journal of chemical information and modeling, 2023-05, Vol.63 (10), p.3043-3053

2023

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology

Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine

Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies

Ion channels as drug targets in central nervous system disorders

Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

COVID-19 Drugs Chloroquine and Hydroxychloroquine, but Not Azithromycin and Remdesivir, Block hERG Potassium Channels

Neural KCNQ (Kv7) channels

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

K Ca channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549)

Towards a Structural View of Drug Binding to hERG K+ Channels

Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade

Differential potassium channel inhibitory activities of a novel thermostable degradation peptide BmKcug1a-P1 from scorpion medicinal material and its N-terminal truncated/restored peptides

Multiple hERG channel blocking pathways: implications for macromolecules

Scorpion Potassium Channel-blocking Defensin Highlights a Functional Link with Neurotoxin

N‐terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage‐gated potassium channel Kv1.3

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

Ions and blockers in potassium channels: insights from free energy simulations

Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K + channel pathway

Crystal Structure of the Human K2P TRAAK, a Lipid-and Mechano-Sensitive K⁺ Ion Channel

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

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