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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie (International ed.), 2021-10, Vol.60 (43), p.23327-23334

International ed. in English, 2021

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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Chemical communications (Cambridge, England), 2022-09, Vol.58 (78), p.1933-1936

2022

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Activating mechanosensitive channels embedded in droplet interface bilayers using membrane asymmetry

Chemical science (Cambridge), 2021-02, Vol.12 (6), p.2138-2145

2021

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UV-DIB: label-free permeability determination using droplet interface bilayers

Lab on a chip, 2022-03, Vol.22 (5), p.972-985

2022

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One-pot synthesis of benzothiazolines and napthathiazolines via cascade ortho-lithiation, cyclisation and elimination of N-arylsulfonyl lactams

Organic & biomolecular chemistry, 2007-01, Vol.5 (21), p.3472-3476

2007

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An Efficient Synthesis of Lactacystin β-Lactone

Angewandte Chemie (International ed.), 2004-04, Vol.43 (17), p.2293-2296

2004

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Utility of the Ammonia-Free Birch Reduction of Electron-Deficient Pyrroles: Total Synthesis of the 20S Proteasome Inhibitor, clasto-Lactacystin β-Lactone

Chemistry : a European journal, 2005-07, Vol.11 (14), p.4227-4238

2005

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Phosphinates as new electrophilic partners for cross-coupling reactions

Organic & biomolecular chemistry, 2008-01, Vol.6 (21), p.4053-4058

2008

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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1588-1592

2011

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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1582-1587

2011

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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.618-622

2010

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(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

Bioorganic & medicinal chemistry letters, 2005-07, Vol.15 (14), p.3402-3406

2005

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Investigation of the importance of nitrogen substituents in a N–P chiral ligand for enantioselective allylic alkylation

Tetrahedron: asymmetry, , Vol.12 (6), p.923-935

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The design of 8,8-Dimethyl[1,6]naphthyridines as potential anticonvulsant agents

Bioorganic & medicinal chemistry letters, 2003-05, Vol.13 (10), p.1627-1629

2003

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Some novel electron transfer mediated cascade ring-opening reactions of bicyclo[4.1.0]ketones

Tetrahedron, 1996-08, Vol.52 (35), p.11421-11444

1996

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A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition

Tetrahedron, 1998-12, Vol.54 (49), p.14905-14912

1998

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Dramatic reversal of enantioselection in a palladium catalysed allylic substitution by choice of nitrogen substituents in a N–P chiral ligand

Tetrahedron: asymmetry, 1999-07, Vol.10 (15), p.2829-2832

1999

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Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides

Bioorganic & medicinal chemistry, 2000-08, Vol.8 (8), p.2085-2094

2000

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Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2903-2906

1998

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Construction of bicyclic systems via a tandem free radical cyclopropylcarbinyl rearrangement-cyclisation strategy

Tetrahedron, 1992, Vol.48 (37), p.8031-8052

1992

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Origins of the regioselectivity of cyclopropylcarbinyl ring opening reactions in bicyclo [n.1.0] systems

Journal of the Chemical Society. Chemical communications, 1992 (13), p.942-944

1992

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A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

SLAS discovery, 2021-08, Vol.26 (7), p.885-895

2021

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Synthesis of a Protected (±)-Calicheamicinone Derivative by Sequential Introduction of Functionality into the Bicyclo[7.3.1]enediyne Core Structure

Journal of the American Chemical Society, 1997-07, Vol.119 (29), p.6739-6748

1997

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Activating mechanosensitive channels embedded in droplet interface bilayers using membrane asymmetry

UV-DIB: label-free permeability determination using droplet interface bilayers

One-pot synthesis of benzothiazolines and napthathiazolines via cascade ortho-lithiation, cyclisation and elimination of N-arylsulfonyl lactams

An Efficient Synthesis of Lactacystin β-Lactone

Utility of the Ammonia-Free Birch Reduction of Electron-Deficient Pyrroles: Total Synthesis of the 20S Proteasome Inhibitor, clasto-Lactacystin β-Lactone

Phosphinates as new electrophilic partners for cross-coupling reactions

The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs

Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs

Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs

(1 H-Imidazo[4,5- c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

Investigation of the importance of nitrogen substituents in a N–P chiral ligand for enantioselective allylic alkylation

The design of 8,8-Dimethyl[1,6]naphthyridines as potential anticonvulsant agents

Some novel electron transfer mediated cascade ring-opening reactions of bicyclo[4.1.0]ketones

A stereoselective synthesis of 3-substituted hexahydroindeno[2,1-b]pyrroles via an intramolecular azomethine ylide cycloaddition

Dramatic reversal of enantioselection in a palladium catalysed allylic substitution by choice of nitrogen substituents in a N–P chiral ligand

Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl- benzamides with potential anticonvulsant activity

Construction of bicyclic systems via a tandem free radical cyclopropylcarbinyl rearrangement-cyclisation strategy

Origins of the regioselectivity of cyclopropylcarbinyl ring opening reactions in bicyclo [n.1.0] systems

A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

Synthesis of a Protected (±)-Calicheamicinone Derivative by Sequential Introduction of Functionality into the Bicyclo[7.3.1]enediyne Core Structure

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