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Computational investigations of hERG channel blockers: New insights and current predictive models

Advanced drug delivery reviews, 2015-06, Vol.86, p.72-82

2015

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Atrial fibrillation: Therapeutic potential of atrial K + channel blockers

Pharmacology & therapeutics (Oxford), 2017-08, Vol.176, p.13-21

2017

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Venom-derived peptide inhibitors of voltage-gated potassium channels

Neuropharmacology, 2017-12, Vol.127, p.124-138

2017

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Towards a Structural View of Drug Binding to hERG K+ Channels

Trends in pharmacological sciences (Regular ed.), 2017-10, Vol.38 (10), p.899-907

2017

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells

European journal of pharmacology, 2024-06, Vol.973, p.176610-176610, Article 176610

2024

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An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

Journal of pharmacological and toxicological methods, 2016-09, Vol.81 (C), p.251-262

2016

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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1283-1291

2019

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sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity

Biochemical pharmacology, 2022-05, Vol.199, p.115023-115023, Article 115023

2022

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Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking

Antiviral research, 2020-07, Vol.179, p.104819-104819, Article 104819

2020

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8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

Journal of ethnopharmacology, 2021-08, Vol.276, p.114168-114168, Article 114168

2021

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Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

European journal of pharmacology, 2011-01, Vol.651 (1-3), p.26-32

2011

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The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

Drug discovery today, 2009-11, Vol.14 (21), p.1011-1020

2009

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A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties

Biochemical pharmacology, 2011-07, Vol.82 (1), p.81-90

2011

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Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential

Bioorganic & medicinal chemistry, 2023-05, Vol.85, p.117276-117276, Article 117276

2023

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Large-conductance, calcium-activated potassium channels: structural and functional implications

Pharmacology & therapeutics (Oxford), 2006-04, Vol.110 (1), p.103-116

2006

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Defensins, a novel type of animal toxin-like potassium channel inhibitor

Toxicon (Oxford), 2019-01, Vol.157, p.101-105

2019

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An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Bioorganic & medicinal chemistry letters, 2019-12, Vol.29 (23), p.126681, Article 126681

2019

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Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3

Biomedicine & pharmacotherapy, 2020-09, Vol.129, p.110383-110383, Article 110383

2020

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Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels

European journal of pharmacology, 2021-08, Vol.905, p.174190-174190, Article 174190

2021

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Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2019-05, Vol.29 (10), p.1241-1245

2019

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Role of Kv7.2/Kv7.3 and M 1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons

European journal of pharmacology, 2019-09, Vol.858, p.172474

2019

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PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

International immunopharmacology, 2019-10, Vol.75, p.105776-105776, Article 105776

2019

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Predicting drug–hERG channel interactions that cause acquired long QT syndrome

Trends in pharmacological sciences (Regular ed.), 2005-03, Vol.26 (3), p.119-124

2005

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Inhibition of cardiac K v 4.3 (I to ) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine

European journal of pharmacology, 2020-08, Vol.880, p.173159

2020

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Computational investigations of hERG channel blockers: New insights and current predictive models

Atrial fibrillation: Therapeutic potential of atrial K + channel blockers

Venom-derived peptide inhibitors of voltage-gated potassium channels

Towards a Structural View of Drug Binding to hERG K+ Channels

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Inhibition of voltage-gated potassium channel by aripiprazole in rabbit coronary arterial smooth muscle cells

An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity

Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking

8-hydroxypinoresinol-4-O-β-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties

Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential

Large-conductance, calcium-activated potassium channels: structural and functional implications

Defensins, a novel type of animal toxin-like potassium channel inhibitor

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3

Relaxation effect of narirutin on rat mesenteric arteries via nitric oxide release and activation of voltage-gated potassium channels

Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Role of Kv7.2/Kv7.3 and M 1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons

PAP-1 ameliorates DSS-induced colitis with involvement of NLRP3 inflammasome pathway

Predicting drug–hERG channel interactions that cause acquired long QT syndrome

Inhibition of cardiac K v 4.3 (I to ) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine

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