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Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells

Cancer research (Chicago, Ill.), 2017-03, Vol.77 (6), p.1427-1438

2017

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Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Scientific reports, 2021-04, Vol.11 (1), p.8515-14, Article 8515

2021

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Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

Nature protocols, 2017-08, Vol.12 (8), p.1639-1658

2017

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A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

The EMBO journal, 2019-01, Vol.38 (2), p.n/a

2019

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Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

PLoS genetics, 2021-01, Vol.17 (1), p.e1009236

2021

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TRPML Cation Channels in Inflammation and Immunity

Frontiers in immunology, 2020-02, Vol.11, p.225

2020

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Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function

Cell death & disease, 2022-08, Vol.13 (8), p.668-14, Article 668

2022

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Gut butyrate-producers confer post-infarction cardiac protection

Nature communications, 2023-11, Vol.14 (1), p.7249-7249, Article 7249

2023

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Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice

Theranostics, 2022, Vol.12 (17), p.7319-7334

2022

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TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

JCI insight, 2020-10, Vol.5 (20)

2020

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Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

Journal of Virology, 2011-09, Vol.85 (17), p.9114-9126

2011

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Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

Science (American Association for the Advancement of Science), 2024-10, Vol.386 (6718), p.eadn5876

2024

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Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

Cell chemical biology, 2021-08, Vol.28 (8), p.1119-1131.e27

2021

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Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells

Journal of cell science, 2022-03, Vol.135 (6)

2022

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Exploring the Dispersion and Electrostatic Components in Arene–Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands

Journal of medicinal chemistry, 2024-02, Vol.67 (3), p.2202-2219

2024

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Endo-Lysosomal Cation Channels and Infectious Diseases

Organelles in Disease, 2023, Vol.185, p.259-276

2023

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TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

Proceedings of the National Academy of Sciences - PNAS, 2017-10, Vol.114 (41), p.E8595-E8602

2017

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Small Molecules for Early Endosome-Specific Patch Clamping

Cell chemical biology, 2017-07, Vol.24 (7), p.907-916.e4

2017

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The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation

Biomaterials, 2022-10, Vol.289, p.121807-121807, Article 121807

2022

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Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library

Antiviral research, 2016-08, Vol.132, p.85-91

2016

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Self-Assembly, Structures, and Photophysical Properties of 4,4′-Bipyrazolate-Linked Metallo-Macrocycles with Dimetal Clips

Inorganic chemistry, 2008-03, Vol.47 (6), p.2142-2154

2008

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The dependence of relaxation rates and chemical shift on the size of the imaged molecules and the concentration of MRI contrast agents

Molecular physics, 2009-11, Vol.107 (21), p.2261-2273

2009

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A fast and accurate network-on-chip timing simulator with a flit propagation model

The 20th Asia and South Pacific Design Automation Conference, 2015, p.797-802

2015

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A ratiometric fluorescent chemosensor for Zn2+ in aqueous solution through an ESIPT coupled AIE process

Sensors and actuators. B, Chemical, 2016-03, Vol.224, p.892-898

2016

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Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

TRPML Cation Channels in Inflammation and Immunity

Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function

Gut butyrate-producers confer post-infarction cardiac protection

Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice

TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway

Helicase-assisted continuous editing for programmable mutagenesis of endogenous genomes

Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells

Exploring the Dispersion and Electrostatic Components in Arene–Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands

Endo-Lysosomal Cation Channels and Infectious Diseases

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

Small Molecules for Early Endosome-Specific Patch Clamping

The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation

Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library

Self-Assembly, Structures, and Photophysical Properties of 4,4′-Bipyrazolate-Linked Metallo-Macrocycles with Dimetal Clips

The dependence of relaxation rates and chemical shift on the size of the imaged molecules and the concentration of MRI contrast agents

A fast and accurate network-on-chip timing simulator with a flit propagation model

A ratiometric fluorescent chemosensor for Zn2+ in aqueous solution through an ESIPT coupled AIE process

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