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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

The Journal of biological chemistry, 2024-04, Vol.300 (4), p.107155-107155, Article 107155

2024

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Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

British journal of pharmacology, 2021-07, Vol.178 (13), p.2617-2631

2021

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Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

Canadian journal of physiology and pharmacology, 2023-01, Vol.101 (1), p.41

2023

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A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels

Journal of ethnopharmacology, 2024-08, Vol.330, p.118218-118218, Article 118218

2024

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Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

The Journal of general physiology, 2019-02, Vol.151 (2), p.214-230

2019

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Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

Journal of chemical information and modeling, 2023-05, Vol.63 (10), p.3043-3053

2023

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A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Bioconjugate chemistry, 2022-11, Vol.33 (11), p.2197-2212

2022

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Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

Pharmacology & therapeutics (Oxford), 2006-07, Vol.111 (1), p.224-259

2006

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KATP Channels in the Cardiovascular System

Physiological reviews, 2016-01, Vol.96 (1), p.177-252

2016

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Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.5916

2015

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Discovery of K V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal research reviews, 2021-07, Vol.41 (4), p.2423-2473

2021

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Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

Science (American Association for the Advancement of Science), 2009-12, Vol.326 (5960), p.1668-1674

2009

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Purlisin, a toxin‐like defensin derived from clinical pathogenic fungus Purpureocillium lilacinum with both antimicrobial and potassium channel inhibitory activities

The FASEB journal, 2020-11, Vol.34 (11), p.15093-15107

2020

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A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels

British journal of pharmacology, 2017-12, Vol.174 (23), p.4396-4408

2017

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Blocking the Passage: C60 Geometrically Clogs K+ Channels

ACS nano, 2015-05, Vol.9 (5), p.4827-4834

2015

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Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels

The Journal of membrane biology, 2023-02, Vol.256 (1), p.63-77

2023

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Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel

Amino acids, 2019-02, Vol.51 (2), p.355

2019

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Mechanisms of gefitinib-induced QT prolongation

European journal of pharmacology, 2021-11, Vol.910, p.174441-174441, Article 174441

2021

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Isolation and structural identification of a potassium ion channel Kv4.1 inhibitor SsTx-P2 from centipede venom

Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2024-04, Vol.53 (2), p.194

2024

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Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

eLife, 2018-11, Vol.7

2018

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Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

Hypertension (Dallas, Tex. 1979), 2011-06, Vol.57 (6), p.1129-1135

2011

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Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability

Journal of neurophysiology, 2016-08, Vol.116 (2), p.456-465

2016

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K V 7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure

American journal of physiology. Renal physiology, 2022-02, Vol.322 (2), p.F197-F207

2022

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Repurposing the K Ca 3.1 Blocker Senicapoc for Ischemic Stroke

Translational stroke research, 2024-06, Vol.15 (3), p.518

2024

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Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

The Journal of biological chemistry, 2014-05, Vol.289 (18), p.12623-12632

2014

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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers

Identification of WP1066, an inhibitor of JAK2 and STAT3, as a K V 1.3 potassium channel blocker

Effect of nitric oxide-cyclic GMP-K + channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom

A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K V 1.3: Role of Conformational Dynamics

A Fluorescent Peptide Toxin for Selective Visualization of the Voltage-Gated Potassium Channel K V 1.3

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

KATP Channels in the Cardiovascular System

Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 Blockers

Discovery of K V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 Å Resolution

Purlisin, a toxin‐like defensin derived from clinical pathogenic fungus Purpureocillium lilacinum with both antimicrobial and potassium channel inhibitory activities

A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels

Blocking the Passage: C60 Geometrically Clogs K+ Channels

Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels

Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel

Mechanisms of gefitinib-induced QT prolongation

Isolation and structural identification of a potassium ion channel Kv4.1 inhibitor SsTx-P2 from centipede venom

Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition

Knockout of the BK β4-subunit promotes a functional coupling of BK channels and ryanodine receptors that mediate a fAHP-induced increase in excitability

K V 7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure

Repurposing the K Ca 3.1 Blocker Senicapoc for Ischemic Stroke

Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma

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