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1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.1999-2006

1999

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1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4685-4691

2013

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1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors

Chemistry & biodiversity, 2010-07, Vol.7 (7), p.1717-1727

2010

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1,2,4-Oxadiazole-5-ones as analogues of tamoxifen: synthesis and biological evaluation

Organic & biomolecular chemistry, 2019-05, Vol.17 (19), p.4892-495

2019

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1,2,4-triazol-3-yl-thiopropyl-tetrahydrobenzazepines: a series of potent and selective dopamine D(3) receptor antagonists

Journal of medicinal chemistry, 2007-10, Vol.50 (21), p.5076

2007

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1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-b-lactamase inhibitors with re-sensitization activity

European journal of medicinal chemistry, 2021-12, Vol.226

2021

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1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives

Journal of medicinal chemistry, 2005-12, Vol.48 (25), p.7932-7945

2005

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1,2,4-Triazolo[1,5- a]quinoxaline derivatives: synthesis and biological evaluation as adenosine receptor antagonists

Farmaco (Società chimica italiana : 1989), 2004-02, Vol.59 (2), p.71-81

2004

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The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A 2A Receptor Subtype

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5772-5790

2017

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1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 3.1 Synthesis and biological properties of aminodeoxystatine and difluorostatone derivatives

Journal of medicinal chemistry, 1991-01, Vol.34 (1), p.151-157

1991

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1,2,4-Triazolo[4,3-a]quinoxalin-1-one: A Versatile Tool for the Synthesis of Potent and Selective Adenosine Receptor Antagonists

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1158-1164

2000

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1,2,4-Triazolo[4,3-a]quinoxalin-1-one Moiety as an Attractive Scaffold To Develop New Potent and Selective Human A3 Adenosine Receptor Antagonists: Synthesis, Pharmacological, and Ligand−Receptor Modeling Studies

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3580-3590

2004

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na V 1.7 inhibition

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (11), p.2103-2108

2018

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1,2,4-Triazolyl azabicyclo[3.1.0]hexanes: a new series of potent and selective dopamine D(3) receptor antagonists

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.374-391

2010

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1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2362-2365

2002

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1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3488-3503

2001

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[1,2-bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. III: Detailed evaluation of the antitumor activity of the enantiomeric complexes on the human NIH:OVCAR-3 ovarian cancer cell line

Journal of cancer research and clinical oncology, 1992-03, Vol.118 (3), p.209-215

1992

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1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl] hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity

Cancer chemotherapy and pharmacology, 2004-04, Vol.53 (4), p.288-295

2004

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1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (7), p.3489-3500

2008

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1,2-disubstituted ferrocenyl carbohydrate chloroquine conjugates as potential antimalarial agents

Dalton transactions : an international journal of inorganic chemistry, 2012-06, Vol.41 (21), p.6431-6442

2012

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1,2-Dithiolan-3-ones and derivatives structurally related to leinamycin. Synthesis and biological evaluation

Farmaco (Società chimica italiana : 1989), 2003-09, Vol.58 (9), p.995-998

2003

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1,25-Dihydroxyvitamin D to PTH(1-84) Ratios Strongly Predict Cardiovascular Death in Heart Failure

PloS one, 2015-08, Vol.10 (8), p.e0135427

2015

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1,25-Dihydroxyvitamin D3 and its analogues inhibit acute myelogenous leukemia progenitor proliferation by suppressing interleukin-1beta production

The Journal of clinical investigation, 1997-10, Vol.100 (7), p.1716-1724

1997

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1,25-dihydroxyvitamin D3 induces LL-37 and HBD-2 production in keratinocytes from diabetic foot ulcers promoting wound healing: an in vitro model

PloS one, 2014-10, Vol.9 (10), p.e111355

2014

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1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia

Leukemia research, 1994-06, Vol.18 (6), p.453-463

1994

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