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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

EMBO molecular medicine, 2017-09, Vol.9 (9), p.1183-1197

2017

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In vivo generated human CAR T cells eradicate tumor cells

Oncoimmunology, 2019-12, Vol.8 (12), p.e1671761-e1671761

2019

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In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

EMBO molecular medicine, 2018-11, Vol.10 (11), p.n/a

2018

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Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Molecular therapy. Methods & clinical development, 2019-03, Vol.12, p.19-31

2019

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Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

PLoS pathogens, 2016-06, Vol.12 (6), p.e1005641-e1005641

2016

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Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

EMBO molecular medicine, 2024-04, Vol.16 (4), p.784-804

2024

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In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma

Journal of experimental & clinical cancer research, 2024-09, Vol.43 (1), p.262-18, Article 262

2024

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Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Molecular therapy, 2013-01, Vol.21 (1), p.109-118

2013

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Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

Molecular therapy, 2022-07, Vol.30 (7), p.2401-2415

2022

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A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Frontiers in immunology, 2017-06, Vol.8, p.676-676

2017

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CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

Frontiers in immunology, 2023-08, Vol.14, p.1183698

2023

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Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

Frontiers in oncology, 2019-02, Vol.9, p.52-52

2019

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DARPins: An Efficient Targeting Domain for Lentiviral Vectors

Molecular therapy, 2011-04, Vol.19 (4), p.686-693

2011

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In vivo generation of CAR T cells in the presence of human myeloid cells

Molecular therapy. Methods & clinical development, 2022-09, Vol.26, p.144-156

2022

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APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Frontiers in cellular neuroscience, 2023-01, Vol.17, p.1106176-1106176

2023

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Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Molecular therapy. Methods & clinical development, 2021-12, Vol.23, p.334-347

2021

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Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

Molecular therapy. Methods & clinical development, 2023-03, Vol.28, p.90-98

2023

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CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

PloS one, 2013-11, Vol.8 (11), p.e79047-e79047

2013

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Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Molecular therapy. Methods & clinical development, 2019-06, Vol.13, p.371-379

2019

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Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo

PloS one, 2014-07, Vol.9 (7), p.e101644-e101644

2014

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Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Trends in biotechnology (Regular ed.), 2015-12, Vol.33 (12), p.777-790

2015

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Virotherapy Research in Germany: From Engineering to Translation

Human gene therapy, 2017-10, Vol.28 (10), p.800-819

2017

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Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

iScience, 2021-03, Vol.24 (3), p.102170-102170, Article 102170

2021

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Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

PloS one, 2012-10, Vol.7 (10), p.e46667-e46667

2012

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CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Advanced science, 2023-12, Vol.10 (35), p.e2302992-n/a

2023

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Clinical development of CAR T cells—challenges and opportunities in translating innovative treatment concepts

In vivo generated human CAR T cells eradicate tumor cells

In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

Surface-Engineered Lentiviral Vectors for Selective Gene Transfer into Subtypes of Lymphocytes

Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models

In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma

Displaying High-affinity Ligands on Adeno-associated Viral Vectors Enables Tumor Cell-specific and Safe Gene Transfer

Precision medicine: In vivo CAR therapy as a showcase for receptor-targeted vector platforms

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes

Tumor-Specific Delivery of Immune Checkpoint Inhibitors by Engineered AAV Vectors

DARPins: An Efficient Targeting Domain for Lentiviral Vectors

In vivo generation of CAR T cells in the presence of human myeloid cells

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8

Dasatinib is a potent enhancer for CAR T cell generation by CD3-targeted lentiviral vectors

CD19 and CD20 targeted vectors induce minimal activation of resting B lymphocytes

Highly Efficient and Selective CAR-Gene Transfer Using CD4- and CD8-Targeted Lentiviral Vectors

Immunization of mice with lentiviral vectors targeted to MHC class II+ cells is due to preferential transduction of dendritic cells in vivo

Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery

Virotherapy Research in Germany: From Engineering to Translation

Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

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